About Gap junction alpha-1 protein
Gap junction alpha-1 protein (GJA1) is a protein
from Homo sapiens identified by UniProt accession
P17302, 382 residues long.
MolForge cross-references it against 0 known binders and
1,189 disease associations.
Target properties
| Protein name | Gap junction alpha-1 protein |
|---|
| UniProt accession | P17302 |
|---|
| Gene | GJA1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 382 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (1189)
Diseases linked to this target (Open Targets).
- oculodentodigital dysplasia · score 0.85
- oculodentodigital dysplasia, autosomal recessive · score 0.79
- autosomal dominant palmoplantar keratoderma and congenital alopecia · score 0.72
- erythrokeratodermia variabilis · score 0.71
- syndactyly type 3 · score 0.71
- craniometaphyseal dysplasia, autosomal recessive · score 0.66
- hypoplastic left heart syndrome 1 · score 0.63
- hypoplastic left heart syndrome · score 0.58
- Hallermann-Streiff syndrome · score 0.56
- familial atrioventricular septal defect · score 0.50
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17302-F1 | alphafold | PREDICTED | 69.84 | — |
Amino-acid sequence (382 residues)
MGDWSALGKL LDKVQAYSTA GGKVWLSVLF IFRILLLGTA VESAWGDEQS AFRCNTQQPG CENVCYDKSF PISHVRFWVL QIIFVSVPTL LYLAHVFYVM RKEEKLNKKE EELKVAQTDG VNVDMHLKQI EIKKFKYGIE EHGKVKMRGG LLRTYIISIL FKSIFEVAFL LIQWYIYGFS LSAVYTCKRD PCPHQVDCFL SRPTEKTIFI IFMLVVSLVS LALNIIELFY VFFKGVKDRV KGKSDPYHAT SGALSPAKDC GSQKYAYFNG CSSPTAPLSP MSPPGYKLVT GDRNNSSCRN YNKQASEQNW ANYSAEQNRM GQAGSTISNS HAQPFDFPDD NQNSKKLAAG HELQPLAIVD QRPSSRASSR ASSRPRPDDL EI
Explore Gap junction alpha-1 protein with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets