Kanamycin

Aminoglycoside Antibacterial — ALIMENTARY TRACT AND METABOLISM

Key facts

Kanamycin is an ofm drug in the Aminoglycoside Antibacterial class catalogued in DrugCentral. It was first approved by the FDA in 1973. DrugCentral lists 4 molecular targets, including mphB, fabH and GJB2. Recorded indications include Bacterial pneumonia, Bacterial septicemia, Burn Wound Infections and Cholangitis.

• Approval status: ofm (first approved 1973 by the FDA).
• Drug class: Aminoglycoside Antibacterial.
• Molecular targets: mphB, fabH, GJB2 and GJA1 (4 listed in DrugCentral).
• Indications: Bacterial pneumonia, Bacterial septicemia, Burn Wound Infections, Cholangitis and Infection of bone and others.
• ATC code: A07AA08 (Antibiotics).
• Molecular formula: C18H36N4O11; molecular weight 484.50 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (11)

• Bacterial pneumonia
• Bacterial septicemia
• Burn Wound Infections
• Cholangitis
• Infection of bone
• Infection of skin AND/OR subcutaneous tissue
• Infectious disease of abdomen
• Infectious disorder of joint
• Meningitis
• Preoperative Bowel Preparation
• Urinary tract infectious disease

Off-label uses (2)

• Acute tuberculosis
• Pulmonary tuberculosis

Contraindications (10)

• Dehydration
• Disorder of the 8th Cranial Nerve
• Hypocalcemia
• Infant Botulism
• Kidney disease
• Myasthenia gravis
• Parkinsonism
• Pregnancy, function
• Tinnitus
• Vertigo

Mechanism & targets

• Established pharmacologic class: Aminoglycoside Antibacterial

Molecular targets (4)

Target	Gene	Action	Activity
Macrolide 2'-phosphotransferase II; Macrolide 2'-phosphotransferase II protein MphB; Macrolide 2-phosphotransferase, mph(B)	mphB	unknown	Km 5.68
3-oxoacyl-[acyl-carrier-protein] synthase 3	fabH	unknown	IC50 5.17
Gap junction beta-2 protein	GJB2	unknown	IC50 5.03
Gap junction alpha-1 protein	GJA1	unknown	IC50 4.32

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1973-02-13	FDA	—	APOTHECON

ATC classification

ATC code	Therapeutic hierarchy
A07AA08	ALIMENTARY TRACT AND METABOLISM › ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS › INTESTINAL ANTIINFECTIVES › Antibiotics
J01GB04	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › AMINOGLYCOSIDE ANTIBACTERIALS › Other aminoglycosides
S01AA24	SENSORY ORGANS › OPHTHALMOLOGICALS › ANTIINFECTIVES › Antibiotics

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Drug resistance	141.0

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Kanamycin is on its molecule page.

• Molecular formula: C₁₈H₃₆N₄O₁₁
• Molecular weight: 484.50 g/mol
• CAS number: —
• InChIKey: SBUJHOSQTJFQJX-NOAMYHISSA-N
• PubChem CID: 6032

NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Kanamycin used for?

DrugCentral lists the following indications for Kanamycin: Bacterial pneumonia, Bacterial septicemia, Burn Wound Infections, Cholangitis, Infection of bone, Infection of skin AND/OR subcutaneous tissue, Infectious disease of abdomen and Infectious disorder of joint and others.

How does Kanamycin work?

Its molecular targets in DrugCentral include mphB, fabH, GJB2 and GJA1.

When was Kanamycin first approved?

Kanamycin was first approved by the FDA in 1973.

What drug class does Kanamycin belong to?

Kanamycin is in the Aminoglycoside Antibacterial class.

What is the chemical formula of Kanamycin?

Kanamycin has the molecular formula C18H36N4O11 and a molecular weight of 484.50 g/mol.

Sources

• DrugCentral drug card 1519 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1384 — compound record and bioactivity
• PubChem CID 6032 — chemical identifiers
• DrugBank DB01172 — drug record
• FDA UNII RUC37XUP2P — substance identity
• DailyMed: FDA labels for Kanamycin — current prescribing information (label search)
• UniProt P29033 (GJB2) — target protein
• UniProt P17302 (GJA1) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.