Gap junction beta-2 protein (GJB2)

About Gap junction beta-2 protein

Gap junction beta-2 protein (GJB2) is a protein from Homo sapiens identified by UniProt accession P29033, 226 residues long. MolForge cross-references it against 0 known binders and 401 disease associations.

Target properties

Protein name	Gap junction beta-2 protein
UniProt accession	P29033
Gene	GJB2
Organism	Homo sapiens
Length	226 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (401)

Diseases linked to this target (Open Targets).

palmoplantar keratoderma-deafness syndrome · score 0.81
Bart-Pumphrey syndrome · score 0.78
keratoderma hereditarium mutilans · score 0.78
autosomal dominant keratitis-ichthyosis-hearing loss syndrome · score 0.77
autosomal dominant nonsyndromic hearing loss 3A · score 0.77
Knuckle pads-leukonychia-sensorineural deafness-palmoplantar hyperkeratosis syndrome · score 0.74
autosomal dominant nonsyndromic hearing loss · score 0.72
hearing loss, autosomal recessive · score 0.71
deafness · score 0.71
hearing loss · score 0.68

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P29033-F1	alphafold	PREDICTED	86.18	—

Amino-acid sequence (226 residues)

MDWGTLQTIL GGVNKHSTSI GKIWLTVLFI FRIMILVVAA KEVWGDEQAD FVCNTLQPGC KNVCYDHYFP ISHIRLWALQ LIFVSTPALL VAMHVAYRRH EKKRKFIKGE IKSEFKDIEE IKTQKVRIEG SLWWTYTSSI FFRVIFEAAF MYVFYVMYDG FSMQRLVKCN AWPCPNTVDC FVSRPTEKTV FTVFMIAVSG ICILLNVTEL CYLLIRYCSG KSKKPV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards