Chymotrypsinogen B (CTRB1)

About Chymotrypsinogen B

Chymotrypsinogen B (CTRB1) is a protein from Homo sapiens identified by UniProt accession P17538, 263 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.

Target properties

Protein name	Chymotrypsinogen B
UniProt accession	P17538
Gene	CTRB1
Organism	Homo sapiens
Length	263 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (49)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.36
appendicular lean mass · score 0.29
type 2 diabetes mellitus · score 0.25
alcoholic pancreatitis · score 0.23
type 1 diabetes mellitus · score 0.22
cutaneous melanoma · score 0.15
diabetes mellitus · score 0.15
prostate cancer · score 0.11
prostate carcinoma · score 0.11
Familial prostate cancer · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P17538-F1	alphafold	PREDICTED	91.75	—

Amino-acid sequence (263 residues)

MASLWLLSCF SLVGAAFGCG VPAIHPVLSG LSRIVNGEDA VPGSWPWQVS LQDKTGFHFC GGSLISEDWV VTAAHCGVRT SDVVVAGEFD QGSDEENIQV LKIAKVFKNP KFSILTVNND ITLLKLATPA RFSQTVSAVC LPSADDDFPA GTLCATTGWG KTKYNANKTP DKLQQAALPL LSNAECKKSW GRRITDVMIC AGASGVSSCM GDSGGPLVCQ KDGAWTLVGI VSWGSDTCST SSPGVYARVT KLIPWVQKIL AAN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards