About Synapsin-1
Synapsin-1 (SYN1) is a protein
from Homo sapiens identified by UniProt accession
P17600, 705 residues long.
MolForge cross-references it against 0 known binders and
172 disease associations.
Target properties
| Protein name | Synapsin-1 |
|---|
| UniProt accession | P17600 |
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| Gene | SYN1 |
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| Organism | Homo sapiens |
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| Length | 705 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (172)
Diseases linked to this target (Open Targets).
- X-linked epilepsy - learning disabilities - behavior disorders · score 0.77
- epilepsy, X-linked 1, with variable learning disabilities and behavior disorders · score 0.70
- X-linked non-syndromic intellectual disability · score 0.68
- genetic disorder · score 0.45
- X-linked complex neurodevelopmental disorder · score 0.37
- Seizure · score 0.34
- Intellectual disability · score 0.31
- autism spectrum disorder · score 0.12
- cutaneous melanoma · score 0.10
- squamous cell lung carcinoma · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17600-F1 | alphafold | PREDICTED | 68.07 | — |
Amino-acid sequence (705 residues)
MNYLRRRLSD SNFMANLPNG YMTDLQRPQP PPPPPGAHSP GATPGPGTAT AERSSGVAPA ASPAAPSPGS SGGGGFFSSL SNAVKQTTAA AAATFSEQVG GGSGGAGRGG AASRVLLVID EPHTDWAKYF KGKKIHGEID IKVEQAEFSD LNLVAHANGG FSVDMEVLRN GVKVVRSLKP DFVLIRQHAF SMARNGDYRS LVIGLQYAGI PSVNSLHSVY NFCDKPWVFA QMVRLHKKLG TEEFPLIDQT FYPNHKEMLS STTYPVVVKM GHAHSGMGKV KVDNQHDFQD IASVVALTKT YATAEPFIDA KYDVRVQKIG QNYKAYMRTS VSGNWKTNTG SAMLEQIAMS DRYKLWVDTC SEIFGGLDIC AVEALHGKDG RDHIIEVVGS SMPLIGDHQD EDKQLIVELV VNKMAQALPR QRQRDASPGR GSHGQTPSPG ALPLGRQTSQ QPAGPPAQQR PPPQGGPPQP GPGPQRQGPP LQQRPPPQGQ QHLSGLGPPA GSPLPQRLPS PTSAPQQPAS QAAPPTQGQG RQSRPVAGGP GAPPAARPPA SPSPQRQAGP PQATRQTSVS GPAPPKASGA PPGGQQRQGP PQKPPGPAGP TRQASQAGPV PRTGPPTTQQ PRPSGPGPAG RPKPQLAQKP SQDVPPPATA AAGGPPHPQL NKSQSLTNAF NLPEPAPPRP SLSQDEVKAE TIRSLRKSFA SLFSD
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