About 5,6-dihydroxyindole-2-carboxylic acid oxidase
5,6-dihydroxyindole-2-carboxylic acid oxidase (TYRP1) is a protein
from Homo sapiens identified by UniProt accession
P17643, 537 residues long.
MolForge cross-references it against 0 known binders and
400 disease associations.
Target properties
| Protein name | 5,6-dihydroxyindole-2-carboxylic acid oxidase |
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| UniProt accession | P17643 |
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| Gene | TYRP1 |
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| Organism | Homo sapiens |
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| Length | 537 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (400)
Diseases linked to this target (Open Targets).
- oculocutaneous albinism type 3 · score 0.79
- hair colour measurement · score 0.68
- skin pigmentation · score 0.64
- oculocutaneous albinism · score 0.62
- skin pigmentation measurement · score 0.56
- oculocutaneous albinism type 6 · score 0.50
- hair color · score 0.49
- cutaneous melanoma · score 0.43
- eye color · score 0.42
- albinism · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P17643-F1 | alphafold | PREDICTED | 91.70 | — |
Amino-acid sequence (537 residues)
MSAPKLLSLG CIFFPLLLFQ QARAQFPRQC ATVEALRSGM CCPDLSPVSG PGTDRCGSSS GRGRCEAVTA DSRPHSPQYP HDGRDDREVW PLRFFNRTCH CNGNFSGHNC GTCRPGWRGA ACDQRVLIVR RNLLDLSKEE KNHFVRALDM AKRTTHPLFV IATRRSEEIL GPDGNTPQFE NISIYNYFVW THYYSVKKTF LGVGQESFGE VDFSHEGPAF LTWHRYHLLR LEKDMQEMLQ EPSFSLPYWN FATGKNVCDI CTDDLMGSRS NFDSTLISPN SVFSQWRVVC DSLEDYDTLG TLCNSTEDGP IRRNPAGNVA RPMVQRLPEP QDVAQCLEVG LFDTPPFYSN STNSFRNTVE GYSDPTGKYD PAVRSLHNLA HLFLNGTGGQ THLSPNDPIF VLLHTFTDAV FDEWLRRYNA DISTFPLENA PIGHNRQYNM VPFWPPVTNT EMFVTAPDNL GYTYEIQWPS REFSVPEIIA IAVVGALLLV ALIFGTASYL IRARRSMDEA NQPLLTDQYQ CYAEEYEKLQ NPNQSVV
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