Insulin-like growth factor-binding protein 3 (IGFBP3)

About Insulin-like growth factor-binding protein 3

Insulin-like growth factor-binding protein 3 (IGFBP3) is a protein from Homo sapiens identified by UniProt accession P17936, 291 residues long. MolForge cross-references it against 0 known binders and 838 disease associations.

Target properties

Protein name	Insulin-like growth factor-binding protein 3
UniProt accession	P17936
Gene	IGFBP3
Organism	Homo sapiens
Length	291 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (838)

Diseases linked to this target (Open Targets).

IGF-1 measurement · score 0.68
pulse pressure measurement · score 0.48
systolic blood pressure · score 0.48
diastolic blood pressure · score 0.47
body height · score 0.44
appendicular lean mass · score 0.39
BMI-adjusted waist-hip ratio · score 0.38
BMI-adjusted waist circumference · score 0.38
blood protein measurement · score 0.37
cortical thickness · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P17936-F1	alphafold	PREDICTED	68.11	—

Amino-acid sequence (291 residues)

MQRARPTLWA AALTLLVLLR GPPVARAGAS SAGLGPVVRC EPCDARALAQ CAPPPAVCAE LVREPGCGCC LTCALSEGQP CGIYTERCGS GLRCQPSPDE ARPLQALLDG RGLCVNASAV SRLRAYLLPA PPAPGNASES EEDRSAGSVE SPSVSSTHRV SDPKFHPLHS KIIIIKKGHA KDSQRYKVDY ESQSTDTQNF SSESKRETEY GPCRREMEDT LNHLKFLNVL SPRGVHIPNC DKKGFYKKKQ CRPSKGRKRG FCWCVDKYGQ PLPGYTTKGK EDVHCYSMQS K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards