3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1)

About 3-oxo-5-alpha-steroid 4-dehydrogenase 1

3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1) is a protein from Homo sapiens identified by UniProt accession P18405, 259 residues long. MolForge cross-references it against 0 known binders and 105 disease associations.

Target properties

Protein name	3-oxo-5-alpha-steroid 4-dehydrogenase 1
UniProt accession	P18405
Gene	SRD5A1
Organism	Homo sapiens
Length	259 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (105)

Diseases linked to this target (Open Targets).

benign prostatic hyperplasia · score 0.60
prostate carcinoma · score 0.57
prostate cancer · score 0.56
alcohol dependence · score 0.46
alcohol abuse · score 0.46
hypogonadism · score 0.45
neoplasm · score 0.40
alopecia · score 0.35
prostate adenocarcinoma · score 0.35
nervous system disease · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P18405-F1	alphafold	PREDICTED	91.53	—

Amino-acid sequence (259 residues)

MATATGVAEE RLLAALAYLQ CAVGCAVFAR NRQTNSVYGR HALPSHRLRV PARAAWVVQE LPSLALPLYQ YASESAPRLR SAPNCILLAM FLVHYGHRCL IYPFLMRGGK PMPLLACTMA IMFCTCNGYL QSRYLSHCAV YADDWVTDPR FLIGFGLWLT GMLINIHSDH ILRNLRKPGD TGYKIPRGGL FEYVTAANYF GEIMEWCGYA LASWSVQGAA FAFFTFCFLS GRAKEHHEWY LRKFEEYPKF RKIIIPFLF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards