About Troponin I, slow skeletal muscle
Troponin I, slow skeletal muscle (TNNI1) is a protein
from Homo sapiens identified by UniProt accession
P19237, 187 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | Troponin I, slow skeletal muscle |
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| UniProt accession | P19237 |
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| Gene | TNNI1 |
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| Organism | Homo sapiens |
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| Length | 187 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (65)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- FEV/FVC ratio · score 0.24
- lung adenocarcinoma · score 0.18
- esophageal cancer · score 0.17
- endometrial cancer · score 0.13
- urinary bladder cancer · score 0.11
- clear cell renal carcinoma · score 0.11
- pacman dysplasia · score 0.06
- tibia, hypoplasia or aplasia of, with polydactyly · score 0.05
- tibial hemimelia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P19237-F1 | alphafold | PREDICTED | 78.11 | — |
Amino-acid sequence (187 residues)
MPEVERKPKI TASRKLLLKS LMLAKAKECW EQEHEEREAE KVRYLAERIP TLQTRGLSLS ALQDLCRELH AKVEVVDEER YDIEAKCLHN TREIKDLKLK VMDLRGKFKR PPLRRVRVSA DAMLRALLGS KHKVSMDLRA NLKSVKKEDT EKERPVEVGD WRKNVEAMSG MEGRKKMFDA AKSPTSQ
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