About Troponin I, cardiac muscle
Troponin I, cardiac muscle (TNNI3) is a protein
from Homo sapiens identified by UniProt accession
P19429, 210 residues long.
MolForge cross-references it against 0 known binders and
600 disease associations.
Target properties
| Protein name | Troponin I, cardiac muscle |
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| UniProt accession | P19429 |
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| Gene | TNNI3 |
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| Organism | Homo sapiens |
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| Length | 210 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (600)
Diseases linked to this target (Open Targets).
- hypertrophic cardiomyopathy · score 0.84
- hypertrophic cardiomyopathy 7 · score 0.81
- cardiomyopathy, familial restrictive, 1 · score 0.77
- dilated cardiomyopathy 1FF · score 0.76
- dilated cardiomyopathy 2A · score 0.68
- heart failure · score 0.58
- cardiomyopathy · score 0.57
- Rare familial disorder with hypertrophic cardiomyopathy · score 0.56
- dilated cardiomyopathy · score 0.55
- Abnormality of the cardiovascular system · score 0.54
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P19429-F1 | alphafold | PREDICTED | 78.60 | — |
Amino-acid sequence (210 residues)
MADGSSDAAR EPRPAPAPIR RRSSNYRAYA TEPHAKKKSK ISASRKLQLK TLLLQIAKQE LEREAEERRG EKGRALSTRC QPLELAGLGF AELQDLCRQL HARVDKVDEE RYDIEAKVTK NITEIADLTQ KIFDLRGKFK RPTLRRVRIS ADAMMQALLG ARAKESLDLR AHLKQVKKED TEKENREVGD WRKNIDALSG MEGRKKKFES
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