About Tumor necrosis factor receptor superfamily member 1A
Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) is a protein
from Homo sapiens identified by UniProt accession
P19438, 455 residues long.
MolForge cross-references it against 0 known binders and
961 disease associations.
Target properties
| Protein name | Tumor necrosis factor receptor superfamily member 1A |
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| UniProt accession | P19438 |
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| Gene | TNFRSF1A |
|---|
| Organism | Homo sapiens |
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| Length | 455 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (961)
Diseases linked to this target (Open Targets).
- autosomal dominant familial periodic fever · score 0.83
- Tumor necrosis factor receptor 1 associated periodic syndrome · score 0.83
- Behcet's syndrome · score 0.46
- lymphocyte count · score 0.41
- autoinflammatory syndrome · score 0.39
- genetic disorder · score 0.39
- eosinophil count · score 0.38
- multiple sclerosis · score 0.37
- primary biliary cirrhosis · score 0.35
- platelet count · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P19438-F1 | alphafold | PREDICTED | 71.36 | — |
Amino-acid sequence (455 residues)
MGLSTVPDLL LPLVLLELLV GIYPSGVIGL VPHLGDREKR DSVCPQGKYI HPQNNSICCT KCHKGTYLYN DCPGPGQDTD CRECESGSFT ASENHLRHCL SCSKCRKEMG QVEISSCTVD RDTVCGCRKN QYRHYWSENL FQCFNCSLCL NGTVHLSCQE KQNTVCTCHA GFFLRENECV SCSNCKKSLE CTKLCLPQIE NVKGTEDSGT TVLLPLVIFF GLCLLSLLFI GLMYRYQRWK SKLYSIVCGK STPEKEGELE GTTTKPLAPN PSFSPTPGFT PTLGFSPVPS STFTSSSTYT PGDCPNFAAP RREVAPPYQG ADPILATALA SDPIPNPLQK WEDSAHKPQS LDTDDPATLY AVVENVPPLR WKEFVRRLGL SDHEIDRLEL QNGRCLREAQ YSMLATWRRR TPRREATLEL LGRVLRDMDL LGCLEDIEEA LCGPAALPPA PSLLR
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