About Spermidine synthase
Spermidine synthase (SRM) is a protein
from Homo sapiens identified by UniProt accession
P19623, 302 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Spermidine synthase |
|---|
| UniProt accession | P19623 |
|---|
| Gene | SRM |
|---|
| Organism | Homo sapiens |
|---|
| Length | 302 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (52)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.10
- serum alanine aminotransferase measurement · score 0.10
- heel bone mineral density · score 0.09
- lean body mass · score 0.09
- appendicular lean mass · score 0.08
- refractive error measurement · score 0.08
- body mass index · score 0.06
- body height · score 0.06
- fat body mass · score 0.06
- base metabolic rate measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P19623-F1 | alphafold | PREDICTED | 94.18 | — |
Amino-acid sequence (302 residues)
MEPGPDGPAA SGPAAIREGW FRETCSLWPG QALSLQVEQL LHHRRSRYQD ILVFRSKTYG NVLVLDGVIQ CTERDEFSYQ EMIANLPLCS HPNPRKVLII GGGDGGVLRE VVKHPSVESV VQCEIDEDVI QVSKKFLPGM AIGYSSSKLT LHVGDGFEFM KQNQDAFDVI ITDSSDPMGP AESLFKESYY QLMKTALKED GVLCCQGECQ WLHLDLIKEM RQFCQSLFPV VAYAYCTIPT YPSGQIGFML CSKNPSTNFQ EPVQPLTQQQ VAQMQLKYYN SDVHRAAFVL PEFARKALND VS
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