About Inter-alpha-trypsin inhibitor heavy chain H1
Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) is a protein
from Homo sapiens identified by UniProt accession
P19827, 911 residues long.
MolForge cross-references it against 0 known binders and
150 disease associations.
Target properties
| Protein name | Inter-alpha-trypsin inhibitor heavy chain H1 |
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| UniProt accession | P19827 |
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| Gene | ITIH1 |
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| Organism | Homo sapiens |
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| Length | 911 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (150)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.37
- osteoarthritis, hip · score 0.24
- pulse pressure measurement · score 0.18
- serum gamma-glutamyl transferase measurement · score 0.13
- psychiatric disorder · score 0.13
- body mass index · score 0.13
- erythrocyte count · score 0.12
- nervous system disease · score 0.11
- eye disease · score 0.11
- lean body mass · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P19827-F1 | alphafold | PREDICTED | 87.44 | — |
Amino-acid sequence (911 residues)
MDGAMGPRGL LLCMYLVSLL ILQAMPALGS ATGRSKSSEK RQAVDTAVDG VFIRSLKVNC KVTSRFAHYV VTSQVVNTAN EAREVAFDLE IPKTAFISDF AVTADGNAFI GDIKDKVTAW KQYRKAAISG ENAGLVRASG RTMEQFTIHL TVNPQSKVTF QLTYEEVLKR NHMQYEIVIK VKPKQLVHHF EIDVDIFEPQ GISKLDAQAS FLPKELAAQT IKKSFSGKKG HVLFRPTVSQ QQSCPTCSTS LLNGHFKVTY DVSRDKICDL LVANNHFAHF FAPQNLTNMN KNVVFVIDIS GSMRGQKVKQ TKEALLKILG DMQPGDYFDL VLFGTRVQSW KGSLVQASEA NLQAAQDFVR GFSLDEATNL NGGLLRGIEI LNQVQESLPE LSNHASILIM LTDGDPTEGV TDRSQILKNV RNAIRGRFPL YNLGFGHNVD FNFLEVMSME NNGRAQRIYE DHDATQQLQG FYSQVAKPLL VDVDLQYPQD AVLALTQNHH KQYYEGSEIV VAGRIADNKQ SSFKADVQAH GEGQEFSITC LVDEEEMKKL LRERGHMLEN HVERLWAYLT IQELLAKRMK VDREERANLS SQALQMSLDY GFVTPLTSMS IRGMADQDGL KPTIDKPSED SPPLEMLGPR RTFVLSALQP SPTHSSSNTQ RLPDRVTGVD TDPHFIIHVP QKEDTLCFNI NEEPGVILSL VQDPNTGFSV NGQLIGNKAR SPGQHDGTYF GRLGIANPAT DFQLEVTPQN ITLNPGFGGP VFSWRDQAVL RQDGVVVTIN KKRNLVVSVD DGGTFEVVLH RVWKGSSVHQ DFLGFYVLDS HRMSARTHGL LGQFFHPIGF EVSDIHPGSD PTKPDATMVV RNRRLTVTRG LQKDYSKDPW HGAEVSCWFI HNNGAGLIDG AYTDYIVPDI F
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