About Thymidine phosphorylase
Thymidine phosphorylase (TYMP) is a protein
from Homo sapiens identified by UniProt accession
P19971, 482 residues long.
MolForge cross-references it against 0 known binders and
90 disease associations.
Target properties
| Protein name | Thymidine phosphorylase |
|---|
| UniProt accession | P19971 |
|---|
| Gene | TYMP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 482 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (90)
Diseases linked to this target (Open Targets).
- mitochondrial DNA depletion syndrome 1 · score 0.80
- mitochondrial neurogastrointestinal encephalomyopathy · score 0.62
- mean reticulocyte volume · score 0.55
- genetic disorder · score 0.47
- colorectal adenocarcinoma · score 0.46
- mean corpuscular volume · score 0.44
- colorectal cancer · score 0.40
- metastatic colorectal cancer · score 0.39
- colorectal neoplasm · score 0.38
- Leukoencephalopathy · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P19971-F1 | alphafold | PREDICTED | 92.40 | — |
Amino-acid sequence (482 residues)
MAALMTPGTG APPAPGDFSG EGSQGLPDPS PEPKQLPELI RMKRDGGRLS EADIRGFVAA VVNGSAQGAQ IGAMLMAIRL RGMDLEETSV LTQALAQSGQ QLEWPEAWRQ QLVDKHSTGG VGDKVSLVLA PALAACGCKV PMISGRGLGH TGGTLDKLES IPGFNVIQSP EQMQVLLDQA GCCIVGQSEQ LVPADGILYA ARDVTATVDS LPLITASILS KKLVEGLSAL VVDVKFGGAA VFPNQEQARE LAKTLVGVGA SLGLRVAAAL TAMDKPLGRC VGHALEVEEA LLCMDGAGPP DLRDLVTTLG GALLWLSGHA GTQAQGAARV AAALDDGSAL GRFERMLAAQ GVDPGLARAL CSGSPAERRQ LLPRAREQEE LLAPADGTVE LVRALPLALV LHELGAGRSR AGEPLRLGVG AELLVDVGQR LRRGTPWLRV HRDGPALSGP QSRALQEALV LSDRAPFAAP SPFAELVLPP QQ
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