About Tumor necrosis factor receptor superfamily member 1B
Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) is a protein
from Homo sapiens identified by UniProt accession
P20333, 461 residues long.
MolForge cross-references it against 0 known binders and
606 disease associations.
Target properties
| Protein name | Tumor necrosis factor receptor superfamily member 1B |
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| UniProt accession | P20333 |
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| Gene | TNFRSF1B |
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| Organism | Homo sapiens |
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| Length | 461 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (606)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.43
- eosinophil percentage of leukocytes · score 0.38
- tumor necrosis factor receptor II measurement · score 0.29
- blood protein measurement · score 0.29
- autoimmune disease · score 0.29
- hypothyroidism · score 0.26
- neurodegenerative disease · score 0.26
- glioblastoma multiforme · score 0.19
- lymphocyte count · score 0.17
- gastric adenocarcinoma · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P20333-F1 | alphafold | PREDICTED | 66.81 | — |
Amino-acid sequence (461 residues)
MAPVAVWAAL AVGLELWAAA HALPAQVAFT PYAPEPGSTC RLREYYDQTA QMCCSKCSPG QHAKVFCTKT SDTVCDSCED STYTQLWNWV PECLSCGSRC SSDQVETQAC TREQNRICTC RPGWYCALSK QEGCRLCAPL RKCRPGFGVA RPGTETSDVV CKPCAPGTFS NTTSSTDICR PHQICNVVAI PGNASMDAVC TSTSPTRSMA PGAVHLPQPV STRSQHTQPT PEPSTAPSTS FLLPMGPSPP AEGSTGDFAL PVGLIVGVTA LGLLIIGVVN CVIMTQVKKK PLCLQREAKV PHLPADKARG TQGPEQQHLL ITAPSSSSSS LESSASALDR RAPTRNQPQA PGVEASGAGE ARASTGSSDS SPGGHGTQVN VTCIVNVCSS SDHSSQCSSQ ASSTMGDTDS SPSESPKDEQ VPFSKEECAF RSQLETPETL LGSTEEKPLP LGVPDAGMKP S
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