Synaptotagmin-1 (SYT1)

About Synaptotagmin-1

Synaptotagmin-1 (SYT1) is a protein from Homo sapiens identified by UniProt accession P21579, 422 residues long. MolForge cross-references it against 0 known binders and 183 disease associations.

Target properties

Protein name	Synaptotagmin-1
UniProt accession	P21579
Gene	SYT1
Organism	Homo sapiens
Length	422 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (183)

Diseases linked to this target (Open Targets).

infantile hypotonia-oculomotor anomalies-hyperkinetic movements-developmental delay syndrome · score 0.73
Intellectual disability · score 0.55
botulism · score 0.55
genetic disorder · score 0.45
intelligence · score 0.38
systolic blood pressure · score 0.38
self reported educational attainment · score 0.38
cognitive function measurement · score 0.38
grip strength measurement · score 0.36
syndromic intellectual disability · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P21579-F1	alphafold	PREDICTED	81.81	—

Amino-acid sequence (422 residues)

MVSESHHEAL AAPPVTTVAT VLPSNATEPA SPGEGKEDAF SKLKEKFMNE LHKIPLPPWA LIAIAIVAVL LVLTCCFCIC KKCLFKKKNK KKGKEKGGKN AINMKDVKDL GKTMKDQALK DDDAETGLTD GEEKEEPKEE EKLGKLQYSL DYDFQNNQLL VGIIQAAELP ALDMGGTSDP YVKVFLLPDK KKKFETKVHR KTLNPVFNEQ FTFKVPYSEL GGKTLVMAVY DFDRFSKHDI IGEFKVPMNT VDFGHVTEEW RDLQSAEKEE QEKLGDICFS LRYVPTAGKL TVVILEAKNL KKMDVGGLSD PYVKIHLMQN GKRLKKKKTT IKKNTLNPYY NESFSFEVPF EQIQKVQVVV TVLDYDKIGK NDAIGKVFVG YNSTGAELRH WSDMLANPRR PIAQWHTLQV EEEVDAMLAV KK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards