About Tumor necrosis factor alpha-induced protein 3
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) is a protein
from Homo sapiens identified by UniProt accession
P21580, 790 residues long.
MolForge cross-references it against 0 known binders and
699 disease associations.
Target properties
| Protein name | Tumor necrosis factor alpha-induced protein 3 |
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| UniProt accession | P21580 |
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| Gene | TNFAIP3 |
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| Organism | Homo sapiens |
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| Length | 790 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (699)
Diseases linked to this target (Open Targets).
- autoinflammatory syndrome, familial, Behcet-like · score 0.65
- autoinflammatory syndrome, familial, Behcet-like 1 · score 0.63
- diffuse large B-cell lymphoma · score 0.54
- autoimmune lymphoproliferative syndrome · score 0.47
- systemic lupus erythematosus · score 0.47
- rheumatoid arthritis · score 0.46
- psoriasis · score 0.45
- eosinophil count · score 0.44
- lymphoid neoplasm · score 0.43
- Hodgkins lymphoma · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P21580-F1 | alphafold | PREDICTED | 73.73 | — |
Amino-acid sequence (790 residues)
MAEQVLPQAL YLSNMRKAVK IRERTPEDIF KPTNGIIHHF KTMHRYTLEM FRTCQFCPQF REIIHKALID RNIQATLESQ KKLNWCREVR KLVALKTNGD GNCLMHATSQ YMWGVQDTDL VLRKALFSTL KETDTRNFKF RWQLESLKSQ EFVETGLCYD TRNWNDEWDN LIKMASTDTP MARSGLQYNS LEEIHIFVLC NILRRPIIVI SDKMLRSLES GSNFAPLKVG GIYLPLHWPA QECYRYPIVL GYDSHHFVPL VTLKDSGPEI RAVPLVNRDR GRFEDLKVHF LTDPENEMKE KLLKEYLMVI EIPVQGWDHG TTHLINAAKL DEANLPKEIN LVDDYFELVQ HEYKKWQENS EQGRREGHAQ NPMEPSVPQL SLMDVKCETP NCPFFMSVNT QPLCHECSER RQKNQNKLPK LNSKPGPEGL PGMALGASRG EAYEPLAWNP EESTGGPHSA PPTAPSPFLF SETTAMKCRS PGCPFTLNVQ HNGFCERCHN ARQLHASHAP DHTRHLDPGK CQACLQDVTR TFNGICSTCF KRTTAEASSS LSTSLPPSCH QRSKSDPSRL VRSPSPHSCH RAGNDAPAGC LSQAARTPGD RTGTSKCRKA GCVYFGTPEN KGFCTLCFIE YRENKHFAAA SGKVSPTASR FQNTIPCLGR ECGTLGSTMF EGYCQKCFIE AQNQRFHEAK RTEEQLRSSQ RRDVPRTTQS TSRPKCARAS CKNILACRSE ELCMECQHPN QRMGPGAHRG EPAPEDPPKQ RCRAPACDHF GNAKCNGYCN ECFQFKQMYG
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