Small proline-rich protein 2E (SPRR2E)

About Small proline-rich protein 2E

Small proline-rich protein 2E (SPRR2E) is a protein from Homo sapiens identified by UniProt accession P22531, 72 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.

Target properties

Protein name	Small proline-rich protein 2E
UniProt accession	P22531
Gene	SPRR2E
Organism	Homo sapiens
Length	72 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (18)

Diseases linked to this target (Open Targets).

prostate adenocarcinoma · score 0.21
head and neck squamous cell carcinoma · score 0.19
gastric adenocarcinoma · score 0.16
endometrial cancer · score 0.10
atopic eczema · score 0.10
esophageal adenocarcinoma · score 0.04
esophageal squamous cell carcinoma · score 0.03
psoriasis · score 0.03
non-small cell lung carcinoma · score 0.02
oral squamous cell carcinoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P22531-F1	alphafold	PREDICTED	77.91	—

Amino-acid sequence (72 residues)

MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPPPK CPQPCPPQQC QQKCPPVTPS PPCQPKCPPK SK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards