Small proline-rich protein 2D (SPRR2D)

About Small proline-rich protein 2D

Small proline-rich protein 2D (SPRR2D) is a protein from Homo sapiens identified by UniProt accession P22532, 72 residues long. MolForge cross-references it against 0 known binders and 21 disease associations.

Target properties

Protein name	Small proline-rich protein 2D
UniProt accession	P22532
Gene	SPRR2D
Organism	Homo sapiens
Length	72 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (21)

Diseases linked to this target (Open Targets).

breast adenocarcinoma · score 0.22
endometrial cancer · score 0.10
psoriasis · score 0.05
non-small cell lung carcinoma · score 0.05
atopic eczema · score 0.04
esophageal adenocarcinoma · score 0.04
esophageal squamous cell carcinoma · score 0.03
neoplasm · score 0.01
cyst · score 0.01
Hyperkeratosis · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P22532-F1	alphafold	PREDICTED	77.69	—

Amino-acid sequence (72 residues)

MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPCPSPK CPQPCPPQQC QQKYPPVTPS PPCQPKCPPK SK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards