Tumor necrosis factor ligand superfamily member 4…

About Tumor necrosis factor ligand superfamily member 4

Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is a protein from Homo sapiens identified by UniProt accession P23510, 183 residues long. MolForge cross-references it against 0 known binders and 346 disease associations.

Target properties

Protein name	Tumor necrosis factor ligand superfamily member 4
UniProt accession	P23510
Gene	TNFSF4
Organism	Homo sapiens
Length	183 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (346)

Diseases linked to this target (Open Targets).

systemic lupus erythematosus · score 0.55
asthma · score 0.48
atopic eczema · score 0.46
Eczematoid dermatitis · score 0.45
rheumatoid arthritis · score 0.44
allergic disease · score 0.41
eosinophil count · score 0.39
childhood onset asthma · score 0.39
total blood protein measurement · score 0.38
allergic rhinitis · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P23510-F1	alphafold	PREDICTED	84.78	—

Amino-acid sequence (183 residues)

MERVQPLEEN VGNAARPRFE RNKLLLVASV IQGLGLLLCF TYICLHFSAL QVSHRYPRIQ SIKVQFTEYK KEKGFILTSQ KEDEIMKVQN NSVIINCDGF YLISLKGYFS QEVNISLHYQ KDEEPLFQLK KVRSVNSLMV ASLTYKDKVY LNVTTDNTSL DDFHVNGGEL ILIHQNPGEF CVL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Tumor necrosis factor ligand superfamily member 4 (TNFSF4)