Inositol-trisphosphate 3-kinase A (ITPKA)

About Inositol-trisphosphate 3-kinase A

Inositol-trisphosphate 3-kinase A (ITPKA) is a protein from Homo sapiens identified by UniProt accession P23677, 461 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.

Target properties

Protein name	Inositol-trisphosphate 3-kinase A
UniProt accession	P23677
Gene	ITPKA
Organism	Homo sapiens
Length	461 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (85)

Diseases linked to this target (Open Targets).

eosinophil count · score 0.34
eosinophil percentage of leukocytes · score 0.29
cystatin C measurement · score 0.23
Eczematoid dermatitis · score 0.22
asthma · score 0.21
allergic rhinitis · score 0.20
cutaneous melanoma · score 0.18
neutrophil count · score 0.17
childhood onset asthma · score 0.16
allergic disease · score 0.16

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P23677-F1	alphafold	PREDICTED	71.48	—

Amino-acid sequence (461 residues)

MTLPGGPTGM ARPGGARPCS PGLERAPRRS VGELRLLFEA RCAAVAAAAA AGEPRARGAK RRGGQVPNGL PRAPPAPVIP QLTVTAEEPD VPPTSPGPPE RERDCLPAAG SSHLQQPRRL STSSVSSTGS SSLLEDSEDD LLSDSESRSR GNVQLEAGED VGQKNHWQKI RTMVNLPVIS PFKKRYAWVQ LAGHTGSFKA AGTSGLILKR CSEPERYCLA RLMADALRGC VPAFHGVVER DGESYLQLQD LLDGFDGPCV LDCKMGVRTY LEEELTKARE RPKLRKDMYK KMLAVDPEAP TEEEHAQRAV TKPRYMQWRE GISSSTTLGF RIEGIKKADG SCSTDFKTTR SREQVLRVFE EFVQGDEEVL RRYLNRLQQI RDTLEVSEFF RRHEVIGSSL LFVHDHCHRA GVWLIDFGKT TPLPDGQILD HRRPWEEGNR EDGYLLGLDN LIGILASLAE R

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards