About Gamma-aminobutyric acid receptor subunit rho-1
Gamma-aminobutyric acid receptor subunit rho-1 (GABRR1) is a protein
from Homo sapiens identified by UniProt accession
P24046, 479 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | Gamma-aminobutyric acid receptor subunit rho-1 |
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| UniProt accession | P24046 |
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| Gene | GABRR1 |
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| Organism | Homo sapiens |
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| Length | 479 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (37)
Diseases linked to this target (Open Targets).
- refractive error · score 0.30
- self reported educational attainment · score 0.30
- diabetic nephropathy · score 0.29
- cutaneous melanoma · score 0.18
- esophageal cancer · score 0.14
- lung adenocarcinoma · score 0.12
- squamous cell lung carcinoma · score 0.12
- breast adenocarcinoma · score 0.10
- breast carcinoma · score 0.04
- sleep duration · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P24046-F1 | alphafold | PREDICTED | 74.01 | — |
Amino-acid sequence (479 residues)
MLAVPNMRFG IFLLWWGWVL ATESRMHWPG REVHEMSKKG RPQRQRREVH EDAHKQVSPI LRRSPDITKS PLTKSEQLLR IDDHDFSMRP GFGGPAIPVG VDVQVESLDS ISEVDMDFTM TLYLRHYWKD ERLSFPSTNN LSMTFDGRLV KKIWVPDMFF VHSKRSFIHD TTTDNVMLRV QPDGKVLYSL RVTVTAMCNM DFSRFPLDTQ TCSLEIESYA YTEDDLMLYW KKGNDSLKTD ERISLSQFLI QEFHTTTKLA FYSSTGWYNR LYINFTLRRH IFFFLLQTYF PATLMVMLSW VSFWIDRRAV PARVPLGITT VLTMSTIITG VNASMPRVSY IKAVDIYLWV SFVFVFLSVL EYAAVNYLTT VQERKEQKLR EKLPCTSGLP PPRTAMLDGN YSDGEVNDLD NYMPENGEKP DRMMVQLTLA SERSSPQRKS QRSSYVSMRI DTHAIDKYSR IIFPAAYILF NLIYWSIFS
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