Lindane

ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS

Key facts

Lindane is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 1974. DrugCentral lists 9 molecular targets, including GABRB3, GABRG2|GABRB3|GABRA6 and Rdl. Recorded indications include Infestation by Phthirus pubis, Infestation by Sarcoptes scabiei var hominis and Pediculosis capitis.

• Approval status: ofm (first approved 1974 by the FDA).
• Molecular targets: GABRB3, GABRG2|GABRB3|GABRA6, Rdl and GABRA1|GABRG2|GABRB3 (9 listed in DrugCentral).
• Indications: Infestation by Phthirus pubis, Infestation by Sarcoptes scabiei var hominis and Pediculosis capitis.
• ATC code: P03AB02 (Chlorine containing products).
• Molecular formula: C6H6Cl6; molecular weight 290.83 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (3)

• Infestation by Phthirus pubis
• Infestation by Sarcoptes scabiei var hominis
• Pediculosis capitis

Contraindications (12)

• Alcoholism
• Atopic dermatitis
• Breastfeeding (mother)
• Cirrhosis of liver
• Disorder of skin
• Injury of head
• Intracerebral Mass
• Lowered convulsive threshold
• Pregnancy, function
• Psoriasis
• Seizure disorder
• Uncontrolled Epilepsy

Mechanism & targets

Molecular targets (9)

Target	Gene	Action	Activity
Gamma-aminobutyric acid receptor subunit beta-3	GABRB3	unknown	IC50 9.05
GABA-A receptor alpha-6/beta-3/gamma-2	GABRG2|GABRB3|GABRA6	unknown	IC50 8.31
Gamma-aminobutyric acid receptor subunit beta	Rdl	unknown	IC50 7.96
GABA-A receptor alpha-1/beta-3/gamma-2	GABRA1|GABRG2|GABRB3	unknown	IC50 7.68
GABA A receptor alpha-1/beta-1/gamma-2	GABRA1|GABRB1|GABRG2	unknown	IC50 7.17
Gamma-aminobutyric acid receptor subunit rho-1	GABRR1	unknown	IC50 7.04
Androgen receptor	Ar	unknown	IC50 4.39
GABA-A receptor	Rdl1|Rdl2|Rdl3	negative allosteric modulator	—
GABA-A receptor	—	negative allosteric modulator	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1974-12-19	FDA	—	REED AND CARNRICK

ATC classification

ATC code	Therapeutic hierarchy
P03AB02	ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS › ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS › ECTOPARASITICIDES, INCL. SCABICIDES › Chlorine containing products

Chemical structure

• Molecular formula: C₆H₆Cl₆
• Molecular weight: 290.83 g/mol
• CAS number: —
• InChIKey: JLYXXMFPNIAWKQ-GNIYUCBRSA-N
• PubChem CID: 727

Cl[C@H]1[C@H](Cl)[C@@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H]1Cl

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Lindane used for?

DrugCentral lists the following indications for Lindane: Infestation by Phthirus pubis, Infestation by Sarcoptes scabiei var hominis and Pediculosis capitis.

How does Lindane work?

Its molecular targets in DrugCentral include GABRB3, GABRG2|GABRB3|GABRA6, Rdl and GABRA1|GABRG2|GABRB3.

When was Lindane first approved?

Lindane was first approved by the FDA in 1974.

What is the chemical formula of Lindane?

Lindane has the molecular formula C6H6Cl6 and a molecular weight of 290.83 g/mol.

Sources

• DrugCentral drug card 1583 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL15891 — compound record and bioactivity
• PubChem CID 727 — chemical identifiers
• DrugBank DB00431 — drug record
• FDA UNII 59NEE7PCAB — substance identity
• DailyMed: FDA labels for Lindane — current prescribing information (label search)
• UniProt P28472 (GABRB3) — target protein
• UniProt P24046 (GABRR1) — target protein

How this page is built: methodology · editorial policy & corrections.