About Gamma-aminobutyric acid receptor subunit beta-3
Gamma-aminobutyric acid receptor subunit beta-3 (GABRB3) is a protein
from Homo sapiens identified by UniProt accession
P28472, 473 residues long.
MolForge cross-references it against 0 known binders and
413 disease associations.
Target properties
| Protein name | Gamma-aminobutyric acid receptor subunit beta-3 |
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| UniProt accession | P28472 |
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| Gene | GABRB3 |
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| Organism | Homo sapiens |
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| Length | 473 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (413)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy, 43 · score 0.78
- Lennox-Gastaut syndrome · score 0.74
- childhood absence epilepsy · score 0.69
- developmental and epileptic encephalopathy · score 0.68
- Seizure · score 0.66
- epilepsy · score 0.61
- migraine disorder · score 0.61
- pain · score 0.60
- alcohol dependence · score 0.60
- delirium · score 0.59
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P28472-F1 | alphafold | PREDICTED | 80.06 | — |
Amino-acid sequence (473 residues)
MWGLAGGRLF GIFSAPVLVA VVCCAQSVND PGNMSFVKET VDKLLKGYDI RLRPDFGGPP VCVGMNIDIA SIDMVSEVNM DYTLTMYFQQ YWRDKRLAYS GIPLNLTLDN RVADQLWVPD TYFLNDKKSF VHGVTVKNRM IRLHPDGTVL YGLRITTTAA CMMDLRRYPL DEQNCTLEIE SYGYTTDDIE FYWRGGDKAV TGVERIELPQ FSIVEHRLVS RNVVFATGAY PRLSLSFRLK RNIGYFILQT YMPSILITIL SWVSFWINYD ASAARVALGI TTVLTMTTIN THLRETLPKI PYVKAIDMYL MGCFVFVFLA LLEYAFVNYI FFGRGPQRQK KLAEKTAKAK NDRSKSESNR VDAHGNILLT SLEVHNEMNE VSGGIGDTRN SAISFDNSGI QYRKQSMPRE GHGRFLGDRS LPHKKTHLRR RSSQLKIKIP DLTDVNAIDR WSRIVFPFTF SLFNLVYWLY YVN
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