C-X-C chemokine receptor type 1 (CXCR1)

About C-X-C chemokine receptor type 1

C-X-C chemokine receptor type 1 (CXCR1) is a protein from Homo sapiens identified by UniProt accession P25024, 350 residues long. MolForge cross-references it against 0 known binders and 604 disease associations.

Target properties

Protein name	C-X-C chemokine receptor type 1
UniProt accession	P25024
Gene	CXCR1
Organism	Homo sapiens
Length	350 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (604)

Diseases linked to this target (Open Targets).

type 1 diabetes mellitus · score 0.35
neutrophil count · score 0.32
leukocyte count · score 0.30
neutrophil percentage of leukocytes · score 0.30
monocyte percentage of leukocytes · score 0.30
lymphocyte percentage of leukocytes · score 0.28
pneumonia · score 0.28
myeloid white cell count · score 0.28
glioblastoma multiforme · score 0.28
COVID-19 · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P25024-F1	alphafold	PREDICTED	78.07	—

Amino-acid sequence (350 residues)

MSNITDPQMW DFDDLNFTGM PPADEDYSPC MLETETLNKY VVIIAYALVF LLSLLGNSLV MLVILYSRVG RSVTDVYLLN LALADLLFAL TLPIWAASKV NGWIFGTFLC KVVSLLKEVN FYSGILLLAC ISVDRYLAIV HATRTLTQKR HLVKFVCLGC WGLSMNLSLP FFLFRQAYHP NNSSPVCYEV LGNDTAKWRM VLRILPHTFG FIVPLFVMLF CYGFTLRTLF KAHMGQKHRA MRVIFAVVLI FLLCWLPYNL VLLADTLMRT QVIQESCERR NNIGRALDAT EILGFLHSCL NPIIYAFIGQ NFRHGFLKIL AMHGLVSKEF LARHRVTSYT SSSVNVSSNL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards