About Cathepsin S
Cathepsin S (CTSS) is a protein
from Homo sapiens identified by UniProt accession
P25774, 331 residues long.
MolForge cross-references it against 0 known binders and
706 disease associations.
Target properties
| Protein name | Cathepsin S |
|---|
| UniProt accession | P25774 |
|---|
| Gene | CTSS |
|---|
| Organism | Homo sapiens |
|---|
| Length | 331 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (706)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.30
- neurodegenerative disease · score 0.30
- lymphocyte count · score 0.28
- cathepsin S measurement · score 0.27
- aspartate aminotransferase measurement · score 0.26
- breast adenocarcinoma · score 0.25
- calcium measurement · score 0.25
- basal cell carcinoma · score 0.24
- HbA1c measurement · score 0.24
- neuroinflammatory disorder · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P25774-F1 | alphafold | PREDICTED | 94.30 | — |
Amino-acid sequence (331 residues)
MKRLVCVLLV CSSAVAQLHK DPTLDHHWHL WKKTYGKQYK EKNEEAVRRL IWEKNLKFVM LHNLEHSMGM HSYDLGMNHL GDMTSEEVMS LMSSLRVPSQ WQRNITYKSN PNRILPDSVD WREKGCVTEV KYQGSCGACW AFSAVGALEA QLKLKTGKLV SLSAQNLVDC STEKYGNKGC NGGFMTTAFQ YIIDNKGIDS DASYPYKAMD QKCQYDSKYR AATCSKYTEL PYGREDVLKE AVANKGPVSV GVDARHPSFF LYRSGVYYEP SCTQNVNHGV LVVGYGDLNG KEYWLVKNSW GHNFGEEGYI RMARNKGNHC GIASFPSYPE I
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