Vaniprevir

Drug profile

Key facts

Vaniprevir is a drug catalogued in DrugCentral. It was first approved by the PMDA in 2014. DrugCentral lists 5 molecular targets, including Genome polyprotein, Nonstructural protein NS3-4A and Genome polyprotein. Recorded indications include Chronic hepatitis C.

• Molecular targets: Genome polyprotein, Nonstructural protein NS3-4A, Genome polyprotein and Genome polyprotein (5 listed in DrugCentral).
• Indications: Chronic hepatitis C.
• Molecular formula: C38H55N5O9S; molecular weight 757.95 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Chronic hepatitis C

Mechanism & targets

Molecular targets (5)

Target	Gene	Action	Activity
Genome polyprotein	—	inhibitor	Ki 10.30
Nonstructural protein NS3-4A	—	unknown	Ki 10.30
Genome polyprotein	—	inhibitor	Ki 9.05
Genome polyprotein	—	unknown	Ki 7.66
Cathepsin S	CTSS	unknown	IC50 4.11

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2014-09-26	PMDA	—	—

Chemical structure

• Molecular formula: C₃₈H₅₅N₅O₉S
• Molecular weight: 757.95 g/mol
• CAS number: —
• InChIKey: KYLWQAGGDVJPKM-ZBVFNZHQSA-N
• PubChem CID: 24765256

CC[C@@H]1C[C@]1(NC(=O)[C@@H]1[C@H]2CCN1C(=O)[C@@H](NC(=O)OCC(C)(C)CCCCC1=C3CN(CC3=CC=C1)C(=O)O2)C(C)(C)C)C(=O)NS(=O)(=O)C1CC1

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Vaniprevir used for?

DrugCentral lists the following indications for Vaniprevir: Chronic hepatitis C.

How does Vaniprevir work?

Its molecular targets in DrugCentral include Genome polyprotein (inhibitor), Nonstructural protein NS3-4A, Genome polyprotein (inhibitor) and Genome polyprotein.

When was Vaniprevir first approved?

Vaniprevir was first approved by the PMDA in 2014.

What is the chemical formula of Vaniprevir?

Vaniprevir has the molecular formula C38H55N5O9S and a molecular weight of 757.95 g/mol.

Sources

• DrugCentral drug card 4939 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL4525964 — compound record and bioactivity
• PubChem CID 24765256 — chemical identifiers
• DrugBank DB11929 — drug record
• FDA UNII CV3X74AO1H — substance identity
• UniProt P25774 (CTSS) — target protein

How this page is built: methodology · editorial policy & corrections.