About 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2) is a protein
from Homo sapiens identified by UniProt accession
P26439, 372 residues long.
MolForge cross-references it against 0 known binders and
93 disease associations.
Target properties
| Protein name | 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 |
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| UniProt accession | P26439 |
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| Gene | HSD3B2 |
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| Organism | Homo sapiens |
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| Length | 372 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (93)
Diseases linked to this target (Open Targets).
- congenital adrenal hyperplasia due to 3-beta-hydroxysteroid dehydrogenase deficiency · score 0.81
- congenital adrenal hyperplasia · score 0.53
- adrenal gland disease · score 0.37
- hypospadias · score 0.27
- metabolite measurement · score 0.21
- genetic disorder · score 0.19
- ovarian cancer · score 0.18
- squamous cell lung carcinoma · score 0.18
- cortical surface area measurement · score 0.13
- ependymoma · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P26439-F1 | alphafold | PREDICTED | 94.41 | — |
Amino-acid sequence (372 residues)
MGWSCLVTGA GGLLGQRIVR LLVEEKELKE IRALDKAFRP ELREEFSKLQ NRTKLTVLEG DILDEPFLKR ACQDVSVVIH TACIIDVFGV THRESIMNVN VKGTQLLLEA CVQASVPVFI YTSSIEVAGP NSYKEIIQNG HEEEPLENTW PTPYPYSKKL AEKAVLAANG WNLKNGDTLY TCALRPTYIY GEGGPFLSAS INEALNNNGI LSSVGKFSTV NPVYVGNVAW AHILALRALR DPKKAPSVRG QFYYISDDTP HQSYDNLNYI LSKEFGLRLD SRWSLPLTLM YWIGFLLEVV SFLLSPIYSY QPPFNRHTVT LSNSVFTFSY KKAQRDLAYK PLYSWEEAKQ KTVEWVGSLV DRHKETLKSK TQ
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