Trilostane

SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS

Key facts

Trilostane is an ofm drug catalogued in DrugCentral. DrugCentral lists 1 molecular target, including HSD3B2. Recorded indications include Hypercortisolism.

• Approval status: ofm.
• Molecular targets: HSD3B2 (1 listed in DrugCentral).
• Indications: Hypercortisolism.
• ATC code: H02CA01 (Anticorticosteroids).
• Molecular formula: C20H27NO3; molecular weight 329.44 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Hypercortisolism

Mechanism & targets

Molecular targets (1)

Target	Gene	Action	Activity
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2	HSD3B2	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	BIOENVISION

ATC classification

ATC code	Therapeutic hierarchy
H02CA01	SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS › CORTICOSTEROIDS FOR SYSTEMIC USE › ANTIADRENAL PREPARATIONS › Anticorticosteroids

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Trilostane is on its molecule page.

• Molecular formula: C₂₀H₂₇NO₃
• Molecular weight: 329.44 g/mol
• CAS number: 13647-35-3
• InChIKey: KVJXBPDAXMEYOA-CXANFOAXSA-N
• PubChem CID: 656583

C[C@]12CC[C@H]3[C@@H](CC[C@@]45O[C@@H]4C(O)=C(C[C@]35C)C#N)[C@@H]1CC[C@@H]2O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Trilostane used for?

DrugCentral lists the following indications for Trilostane: Hypercortisolism.

How does Trilostane work?

Its molecular targets in DrugCentral include HSD3B2 (inhibitor).

What is the chemical formula of Trilostane?

Trilostane has the molecular formula C20H27NO3 and a molecular weight of 329.44 g/mol.

Sources

• DrugCentral drug card 2746 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200907 — compound record and bioactivity
• PubChem CID 656583 — chemical identifiers
• DrugBank DB01108 — drug record
• FDA UNII L0FPV48Q5R — substance identity
• DailyMed: FDA labels for Trilostane — current prescribing information (label search)
• UniProt P26439 (HSD3B2) — target protein

How this page is built: methodology · editorial policy & corrections.