Isovaleryl-CoA dehydrogenase, mitochondrial (IVD)

About Isovaleryl-CoA dehydrogenase, mitochondrial

Isovaleryl-CoA dehydrogenase, mitochondrial (IVD) is a protein from Homo sapiens identified by UniProt accession P26440, 426 residues long. MolForge cross-references it against 0 known binders and 93 disease associations.

Target properties

Protein name	Isovaleryl-CoA dehydrogenase, mitochondrial
UniProt accession	P26440
Gene	IVD
Organism	Homo sapiens
Length	426 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (93)

Diseases linked to this target (Open Targets).

isovaleric acidemia · score 0.85
genetic disorder · score 0.46
testosterone measurement · score 0.30
blood metabolite measurement · score 0.27
vital capacity · score 0.23
idiopathic pulmonary fibrosis · score 0.23
interstitial lung disease · score 0.21
metabolite measurement · score 0.21
serum metabolite measurement · score 0.21
isovalerylcarnitine measurement · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P26440-F1	alphafold	PREDICTED	93.37	—

Amino-acid sequence (426 residues)

MAEMATATRL LGWRVASWRL RPPLAGFVSQ RAHSLLPVDD AINGLSEEQR QLRQTMAKFL QEHLAPKAQE IDRSNEFKNL REFWKQLGNL GVLGITAPVQ YGGSGLGYLE HVLVMEEISR ASGAVGLSYG AHSNLCINQL VRNGNEAQKE KYLPKLISGE YIGALAMSEP NAGSDVVSMK LKAEKKGNHY ILNGNKFWIT NGPDADVLIV YAKTDLAAVP ASRGITAFIV EKGMPGFSTS KKLDKLGMRG SNTCELIFED CKIPAANILG HENKGVYVLM SGLDLERLVL AGGPLGLMQA VLDHTIPYLH VREAFGQKIG HFQLMQGKMA DMYTRLMACR QYVYNVAKAC DEGHCTAKDC AGVILYSAEC ATQVALDGIQ CFGGNGYIND FPMGRFLRDA KLYEIGAGTS EVRRLVIGRA FNADFH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards