About Phosphatidylinositol 3-kinase regulatory subunit alpha
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) is a protein
from Homo sapiens identified by UniProt accession
P27986, 724 residues long.
MolForge cross-references it against 0 known binders and
729 disease associations.
Target properties
| Protein name | Phosphatidylinositol 3-kinase regulatory subunit alpha |
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| UniProt accession | P27986 |
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| Gene | PIK3R1 |
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| Organism | Homo sapiens |
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| Length | 724 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (729)
Diseases linked to this target (Open Targets).
- SHORT syndrome · score 0.83
- immunodeficiency 36 · score 0.76
- agammaglobulinemia 7, autosomal recessive · score 0.76
- cancer · score 0.62
- endometrial cancer · score 0.61
- bone development disease · score 0.56
- neurodegenerative disease · score 0.53
- glioblastoma multiforme · score 0.51
- mean corpuscular volume · score 0.50
- genetic disorder · score 0.50
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P27986-F1 | alphafold | PREDICTED | 83.16 | — |
Amino-acid sequence (724 residues)
MSAEGYQYRA LYDYKKEREE DIDLHLGDIL TVNKGSLVAL GFSDGQEARP EEIGWLNGYN ETTGERGDFP GTYVEYIGRK KISPPTPKPR PPRPLPVAPG SSKTEADVEQ QALTLPDLAE QFAPPDIAPP LLIKLVEAIE KKGLECSTLY RTQSSSNLAE LRQLLDCDTP SVDLEMIDVH VLADAFKRYL LDLPNPVIPA AVYSEMISLA PEVQSSEEYI QLLKKLIRSP SIPHQYWLTL QYLLKHFFKL SQTSSKNLLN ARVLSEIFSP MLFRFSAASS DNTENLIKVI EILISTEWNE RQPAPALPPK PPKPTTVANN GMNNNMSLQD AEWYWGDISR EEVNEKLRDT ADGTFLVRDA STKMHGDYTL TLRKGGNNKL IKIFHRDGKY GFSDPLTFSS VVELINHYRN ESLAQYNPKL DVKLLYPVSK YQQDQVVKED NIEAVGKKLH EYNTQFQEKS REYDRLYEEY TRTSQEIQMK RTAIEAFNET IKIFEEQCQT QERYSKEYIE KFKREGNEKE IQRIMHNYDK LKSRISEIID SRRRLEEDLK KQAAEYREID KRMNSIKPDL IQLRKTRDQY LMWLTQKGVR QKKLNEWLGN ENTEDQYSLV EDDEDLPHHD EKTWNVGSSN RNKAENLLRG KRDGTFLVRE SSKQGCYACS VVVDGEVKHC VINKTATGYG FAEPYNLYSS LKELVLHYQH TSLVQHNDSL NVTLAYPVYA QQRR
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