Tropomodulin-1 (TMOD1)

About Tropomodulin-1

Tropomodulin-1 (TMOD1) is a protein from Homo sapiens identified by UniProt accession P28289, 359 residues long. MolForge cross-references it against 0 known binders and 148 disease associations.

Target properties

Protein name	Tropomodulin-1
UniProt accession	P28289
Gene	TMOD1
Organism	Homo sapiens
Length	359 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (148)

Diseases linked to this target (Open Targets).

Barrett's esophagus · score 0.44
brain aneurysm · score 0.33
FEV/FVC ratio · score 0.32
esophageal adenocarcinoma · score 0.32
neurodegenerative disease · score 0.27
breast adenocarcinoma · score 0.23
sex hormone-binding globulin measurement · score 0.22
lung adenocarcinoma · score 0.19
gastric adenocarcinoma · score 0.18
glioblastoma multiforme · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P28289-F1	alphafold	PREDICTED	84.58	—

Amino-acid sequence (359 residues)

MSYRRELEKY RDLDEDEILG ALTEEELRTL ENELDELDPD NALLPAGLRQ KDQTTKAPTG PFKREELLDH LEKQAKEFKD REDLVPYTGE KRGKVWVPKQ KPLDPVLESV TLEPELEEAL ANASDAELCD IAAILGMHTL MSNQQYYQAL SSSSIMNKEG LNSVIKPTQY KPVPDEEPNS TDVEETLERI KNNDPKLEEV NLNNIRNIPI PTLKAYAEAL KENSYVKKFS IVGTRSNDPV AYALAEMLKE NKVLKTLNVE SNFISGAGIL RLVEALPYNT SLVEMKIDNQ SQPLGNKVEM EIVSMLEKNA TLLKFGYHFT QQGPRLRASN AMMNNNDLVR KRRLADLTGP IIPKCRSGV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards