Transcriptional enhancer factor TEF-1 (TEAD1)

About Transcriptional enhancer factor TEF-1

Transcriptional enhancer factor TEF-1 (TEAD1) is a protein from Homo sapiens identified by UniProt accession P28347, 426 residues long. MolForge cross-references it against 0 known binders and 370 disease associations.

Target properties

Protein name	Transcriptional enhancer factor TEF-1
UniProt accession	P28347
Gene	TEAD1
Organism	Homo sapiens
Length	426 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (370)

Diseases linked to this target (Open Targets).

helicoid peripapillary chorioretinal degeneration · score 0.60
self reported educational attainment · score 0.49
neutrophil count · score 0.46
body height · score 0.46
body fat percentage · score 0.44
vital capacity · score 0.43
heel bone mineral density · score 0.41
fat body mass · score 0.40
alkaline phosphatase measurement · score 0.39
intelligence · score 0.38

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P28347-F1	alphafold	PREDICTED	76.48	—

Amino-acid sequence (426 residues)

MEPSSWSGSE SPAENMERMS DSADKPIDND AEGVWSPDIE QSFQEALAIY PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARR KSRDFHSKLK DQTAKDKALQ HMAAMSSAQI VSATAIHNKL GLPGIPRPTF PGAPGFWPGM IQTGQPGSSQ DVKPFVQQAY PIQPAVTAPI PGFEPASAPA PSVPAWQGRS IGTTKLRLVE FSAFLEQQRD PDSYNKHLFV HIGHANHSYS DPLLESVDIR QIYDKFPEKK GGLKELFGKG PQNAFFLVKF WADLNCNIQD DAGAFYGVTS QYESSENMTV TCSTKVCSFG KQVVEKVETE YARFENGRFV YRINRSPMCE YMINFIHKLK HLPEKYMMNS VLENFTILLV VTNRDTQETL LCMACVFEVS NSEHGAQHHI YRLVKD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards