Pirlindole
Drug profile
Also known as: pirlindol, pirlindole HCl, pirlindole hydrochloride, pirlindole mesilate, pirlindole mesylate, pyrazidol, pyrlindole
Data last refreshed: (DrugCentral release 2024-11-01)
Key facts
Pirlindole is a drug catalogued in DrugCentral. DrugCentral lists 5 molecular targets, including MAOA, TEAD1 and TEAD2. Recorded indications include Depressive disorder.
- Molecular targets: MAOA, TEAD1, TEAD2 and TEAD4 (5 listed in DrugCentral).
- Indications: Depressive disorder.
- Molecular formula: C15H18N2; molecular weight 226.32 g/mol.
Indications & contraindications
Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).
Indications (1)
- Depressive disorder
Mechanism & targets
Molecular targets (5)
| Target | Gene | Action | Activity |
|---|---|---|---|
| Amine oxidase [flavin-containing] A | MAOA | inhibitor | Ki 7.41 |
| Transcriptional enhancer factor TEF-1 | TEAD1 | unknown | Kd 4.92 |
| Transcriptional enhancer factor TEF-4 | TEAD2 | unknown | IC50 4.48 |
| Transcriptional enhancer factor TEF-3 | TEAD4 | unknown | IC50 4.44 |
| Transcriptional enhancer factor TEF-5 | TEAD3 | unknown | IC50 4.36 |
Chemical structure
| Molecular formula | C15H18N2 |
|---|---|
| Molecular weight | 226.32 g/mol |
| CAS number | 60762-57-4 |
| InChIKey | IWVRVEIKCBFZNF-UHFFFAOYSA-N |
| PubChem CID | 68802 |
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
What is Pirlindole used for?
DrugCentral lists the following indications for Pirlindole: Depressive disorder.
How does Pirlindole work?
Its molecular targets in DrugCentral include MAOA (inhibitor), TEAD1, TEAD2 and TEAD4.
What is the chemical formula of Pirlindole?
Pirlindole has the molecular formula C15H18N2 and a molecular weight of 226.32 g/mol.
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Sources
- DrugCentral drug card 2206 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
- ChEMBL CHEMBL32350 — compound record and bioactivity
- PubChem CID 68802 — chemical identifiers
- DrugBank DB09244 — drug record
- FDA UNII V39YPH45FZ — substance identity
- UniProt P21397 (MAOA) — target protein
- UniProt P28347 (TEAD1) — target protein
- UniProt Q15562 (TEAD2) — target protein
- UniProt Q15561 (TEAD4) — target protein
- UniProt Q99594 (TEAD3) — target protein
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