About Transcriptional enhancer factor TEF-5
Transcriptional enhancer factor TEF-5 (TEAD3) is a protein
from Homo sapiens identified by UniProt accession
Q99594, 435 residues long.
MolForge cross-references it against 0 known binders and
56 disease associations.
Target properties
| Protein name | Transcriptional enhancer factor TEF-5 |
|---|
| UniProt accession | Q99594 |
|---|
| Gene | TEAD3 |
|---|
| Organism | Homo sapiens |
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| Length | 435 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (56)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- appendicular lean mass · score 0.28
- body fat percentage · score 0.15
- platelet component distribution width · score 0.09
- insomnia measurement · score 0.09
- fat body mass · score 0.08
- lymphocyte count · score 0.07
- birth weight · score 0.07
- FEV/FVC ratio · score 0.05
- lean body mass · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99594-F1 | alphafold | PREDICTED | 75.56 | — |
Amino-acid sequence (435 residues)
MASNSWNASS SPGEAREDGP EGLDKGLDND AEGVWSPDIE QSFQEALAIY PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARK KVREYQVGIK AMNLDQVSKD KALQSMASMS SAQIVSASVL QNKFSPPSPL PQAVFSTSSR FWSSPPLLGQ QPGPSQDIKP FAQPAYPIQP PLPPTLSSYE PLAPLPSAAA SVPVWQDRTI ASSRLRLLEY SAFMEVQRDP DTYSKHLFVH IGQTNPAFSD PPLEAVDVRQ IYDKFPEKKG GLKELYEKGP PNAFFLVKFW ADLNSTIQEG PGAFYGVSSQ YSSADSMTIS VSTKVCSFGK QVVEKVETEY ARLENGRFVY RIHRSPMCEY MINFIHKLKH LPEKYMMNSV LENFTILQVV TSRDSQETLL VIAFVFEVST SEHGAQHHVY KLVKD
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