About Transcriptional enhancer factor TEF-3
Transcriptional enhancer factor TEF-3 (TEAD4) is a protein
from Homo sapiens identified by UniProt accession
Q15561, 434 residues long.
MolForge cross-references it against 0 known binders and
131 disease associations.
Target properties
| Protein name | Transcriptional enhancer factor TEF-3 |
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| UniProt accession | Q15561 |
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| Gene | TEAD4 |
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| Organism | Homo sapiens |
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| Length | 434 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (131)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- FEV/FVC ratio · score 0.31
- hepatocellular carcinoma · score 0.10
- neoplasm · score 0.10
- bladder transitional cell carcinoma · score 0.10
- head and neck squamous cell carcinoma · score 0.08
- cancer · score 0.08
- lung adenocarcinoma · score 0.08
- benign prostatic hyperplasia · score 0.07
- glioblastoma multiforme · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15561-F1 | alphafold | PREDICTED | 75.20 | — |
Amino-acid sequence (434 residues)
MEGTAGTITS NEWSSPTSPE GSTASGGSQA LDKPIDNDAE GVWSPDIEQS FQEALAIYPP CGRRKIILSD EGKMYGRNEL IARYIKLRTG KTRTRKQVSS HIQVLARRKA REIQAKLKDQ AAKDKALQSM AAMSSAQIIS ATAFHSSMAL ARGPGRPAVS GFWQGALPGQ AGTSHDVKPF SQQTYAVQPP LPLPGFESPA GPAPSPSAPP APPWQGRSVA SSKLWMLEFS AFLEQQQDPD TYNKHLFVHI GQSSPSYSDP YLEAVDIRQI YDKFPEKKGG LKDLFERGPS NAFFLVKFWA DLNTNIEDEG SSFYGVSSQY ESPENMIITC STKVCSFGKQ VVEKVETEYA RYENGHYSYR IHRSPLCEYM INFIHKLKHL PEKYMMNSVL ENFTILQVVT NRDTQETLLC IAYVFEVSAS EHGAQHHIYR LVKE
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