About Transcriptional enhancer factor TEF-4
Transcriptional enhancer factor TEF-4 (TEAD2) is a protein
from Homo sapiens identified by UniProt accession
Q15562, 447 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | Transcriptional enhancer factor TEF-4 |
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| UniProt accession | Q15562 |
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| Gene | TEAD2 |
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| Organism | Homo sapiens |
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| Length | 447 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (86)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- appendicular lean mass · score 0.14
- blood protein measurement · score 0.12
- hepatocellular carcinoma · score 0.09
- isolated spina bifida · score 0.07
- anencephaly 1 · score 0.06
- spina bifida-hypospadias syndrome · score 0.05
- systemic lupus erythematosus · score 0.04
- mean platelet volume · score 0.04
- multiple sclerosis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15562-F1 | alphafold | PREDICTED | 70.72 | — |
Amino-acid sequence (447 residues)
MGEPRAGAAL DDGSGWTGSE EGSEEGTGGS EGAGGDGGPD AEGVWSPDIE QSFQEALAIY PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARR KSREIQSKLK DQVSKDKAFQ TMATMSSAQL ISAPSLQAKL GPTGPQASEL FQFWSGGSGP PWNVPDVKPF SQTPFTLSLT PPSTDLPGYE PPQALSPLPP PTPSPPAWQA RGLGTARLQL VEFSAFVEPP DAVDSYQRHL FVHISQHCPS PGAPPLESVD VRQIYDKFPE KKGGLRELYD RGPPHAFFLV KFWADLNWGP SGEEAGAGGS ISSGGFYGVS SQYESLEHMT LTCSSKVCSF GKQVVEKVET ERAQLEDGRF VYRLLRSPMC EYLVNFLHKL RQLPERYMMN SVLENFTILQ VVTNRDTQEL LLCTAYVFEV STSERGAQHH IYRLVRD
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