About Tumor necrosis factor receptor superfamily member 8
Tumor necrosis factor receptor superfamily member 8 (TNFRSF8) is a protein
from Homo sapiens identified by UniProt accession
P28908, 595 residues long.
MolForge cross-references it against 0 known binders and
559 disease associations.
Target properties
| Protein name | Tumor necrosis factor receptor superfamily member 8 |
|---|
| UniProt accession | P28908 |
|---|
| Gene | TNFRSF8 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 595 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (559)
Diseases linked to this target (Open Targets).
- Hodgkins lymphoma · score 0.58
- lymphoma · score 0.52
- anaplastic large cell lymphoma · score 0.48
- non-Hodgkins lymphoma · score 0.47
- eosinophil count · score 0.46
- asthma · score 0.44
- eosinophil percentage of leukocytes · score 0.44
- neoplasm · score 0.41
- classic Hodgkin lymphoma · score 0.39
- diffuse large B-cell lymphoma · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P28908-F1 | alphafold | PREDICTED | 61.21 | — |
Amino-acid sequence (595 residues)
MRVLLAALGL LFLGALRAFP QDRPFEDTCH GNPSHYYDKA VRRCCYRCPM GLFPTQQCPQ RPTDCRKQCE PDYYLDEADR CTACVTCSRD DLVEKTPCAW NSSRVCECRP GMFCSTSAVN SCARCFFHSV CPAGMIVKFP GTAQKNTVCE PASPGVSPAC ASPENCKEPS SGTIPQAKPT PVSPATSSAS TMPVRGGTRL AQEAASKLTR APDSPSSVGR PSSDPGLSPT QPCPEGSGDC RKQCEPDYYL DEAGRCTACV SCSRDDLVEK TPCAWNSSRT CECRPGMICA TSATNSCARC VPYPICAAET VTKPQDMAEK DTTFEAPPLG TQPDCNPTPE NGEAPASTSP TQSLLVDSQA SKTLPIPTSA PVALSSTGKP VLDAGPVLFW VILVLVVVVG SSAFLLCHRR ACRKRIRQKL HLCYPVQTSQ PKLELVDSRP RRSSTQLRSG ASVTEPVAEE RGLMSQPLME TCHSVGAAYL ESLPLQDASP AGGPSSPRDL PEPRVSTEHT NNKIEKIYIM KADTVIVGTV KAELPEGRGL AGPAEPELEE ELEADHTPHY PEQETEPPLG SCSDVMLSVE EEGKEDPLPT AASGK
Explore Tumor necrosis factor receptor superfamily member 8 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets