Somatostatin receptor type 1 (SSTR1)

About Somatostatin receptor type 1

Somatostatin receptor type 1 (SSTR1) is a protein from Homo sapiens identified by UniProt accession P30872, 391 residues long. MolForge cross-references it against 0 known binders and 218 disease associations.

Target properties

Protein name	Somatostatin receptor type 1
UniProt accession	P30872
Gene	SSTR1
Organism	Homo sapiens
Length	391 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (218)

Diseases linked to this target (Open Targets).

acromegaly · score 0.60
neoplasm · score 0.59
neuroendocrine neoplasm · score 0.59
carcinoid tumor · score 0.55
digestive system neuroendocrine neoplasm · score 0.54
carcinoid syndrome · score 0.52
obesity · score 0.51
cirrhosis of liver · score 0.50
pituitary-dependent Cushing's disease · score 0.48
esophageal varices · score 0.46

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P30872-F1	alphafold	PREDICTED	78.84	—

Amino-acid sequence (391 residues)

MFPNGTASSP SSSPSPSPGS CGEGGGSRGP GAGAADGMEE PGRNASQNGT LSEGQGSAIL ISFIYSVVCL VGLCGNSMVI YVILRYAKMK TATNIYILNL AIADELLMLS VPFLVTSTLL RHWPFGALLC RLVLSVDAVN MFTSIYCLTV LSVDRYVAVV HPIKAARYRR PTVAKVVNLG VWVLSLLVIL PIVVFSRTAA NSDGTVACNM LMPEPAQRWL VGFVLYTFLM GFLLPVGAIC LCYVLIIAKM RMVALKAGWQ QRKRSERKIT LMVMMVVMVF VICWMPFYVV QLVNVFAEQD DATVSQLSVI LGYANSCANP ILYGFLSDNF KRSFQRILCL SWMDNAAEEP VDYYATALKS RAYSVEDFQP ENLESGGVFR NGTCTSRITT L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards