3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)

About 3-oxo-5-alpha-steroid 4-dehydrogenase 2

3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2) is a protein from Homo sapiens identified by UniProt accession P31213, 254 residues long. MolForge cross-references it against 0 known binders and 142 disease associations.

Target properties

Protein name	3-oxo-5-alpha-steroid 4-dehydrogenase 2
UniProt accession	P31213
Gene	SRD5A2
Organism	Homo sapiens
Length	254 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (142)

Diseases linked to this target (Open Targets).

46,XY disorder of sex development due to 5-alpha-reductase 2 deficiency · score 0.84
benign prostatic hyperplasia · score 0.62
prostate carcinoma · score 0.60
androgenetic alopecia · score 0.59
prostate cancer · score 0.56
alcohol dependence · score 0.46
hypotrichosis · score 0.46
alcohol abuse · score 0.46
hypogonadism · score 0.45
Micropenis · score 0.42

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P31213-F1	alphafold	PREDICTED	94.42	—

Amino-acid sequence (254 residues)

MQVQCQQSPV LAGSATLVAL GALALYVAKP SGYGKHTESL KPAATRLPAR AAWFLQELPS FAVPAGILAR QPLSLFGPPG TVLLGLFCLH YFHRTFVYSL LNRGRPYPAI LILRGTAFCT GNGVLQGYYL IYCAEYPDGW YTDIRFSLGV FLFILGMGIN IHSDYILRQL RKPGEISYRI PQGGLFTYVS GANFLGEIIE WIGYALATWS LPALAFAFFS LCFLGLRAFH HHRFYLKMFE DYPKSRKALI PFIF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards