T-cell leukemia homeobox protein 1 (TLX1)

About T-cell leukemia homeobox protein 1

T-cell leukemia homeobox protein 1 (TLX1) is a protein from Homo sapiens identified by UniProt accession P31314, 330 residues long. MolForge cross-references it against 0 known binders and 189 disease associations.

Target properties

Protein name	T-cell leukemia homeobox protein 1
UniProt accession	P31314
Gene	TLX1
Organism	Homo sapiens
Length	330 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (189)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.48
colorectal adenocarcinoma · score 0.38
gastric carcinoma · score 0.37
bile duct carcinoma · score 0.37
mean corpuscular volume · score 0.36
platelet component distribution width · score 0.33
HbA1c measurement · score 0.29
esophageal adenocarcinoma · score 0.29
urinary bladder carcinoma · score 0.29
breast carcinoma · score 0.28

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P31314-F1	alphafold	PREDICTED	61.96	—

Amino-acid sequence (330 residues)

MEHLGPHHLH PGHAEPISFG IDQILNSPDQ GGCMGPASRL QDGEYGLGCL VGGAYTYGGG GSAAATGAGG AGAYGTGGPG GPGGPAGGGG ACSMGPLTGS YNVNMALAGG PGPGGGGGSS GGAGALSAAG VIRVPAHRPL AGAVAHPQPL ATGLPTVPSV PAMPGVNNLT GLTFPWMESN RRYTKDRFTG HPYQNRTPPK KKKPRTSFTR LQICELEKRF HRQKYLASAE RAALAKALKM TDAQVKTWFQ NRRTKWRRQT AEEREAERQQ ANRILLQLQQ EAFQKSLAQP LPADPLCVHN SSLFALQNLQ PWSDDSTKIT SVTSVASACE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards