About RAC-alpha serine/threonine-protein kinase
RAC-alpha serine/threonine-protein kinase (AKT1) is a protein
from Homo sapiens identified by UniProt accession
P31749, 480 residues long.
MolForge cross-references it against 0 known binders and
2,060 disease associations.
Target properties
| Protein name | RAC-alpha serine/threonine-protein kinase |
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| UniProt accession | P31749 |
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| Gene | AKT1 |
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| Organism | Homo sapiens |
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| Length | 480 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (2060)
Diseases linked to this target (Open Targets).
- Proteus syndrome · score 0.79
- cancer · score 0.70
- Cowden syndrome 6 · score 0.70
- breast adenocarcinoma · score 0.68
- breast carcinoma · score 0.67
- colorectal adenocarcinoma · score 0.61
- ovarian carcinoma · score 0.58
- prostate adenocarcinoma · score 0.56
- endometrial cancer · score 0.51
- breast neoplasm · score 0.48
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P31749-F1 | alphafold | PREDICTED | 83.05 | — |
Amino-acid sequence (480 residues)
MSDVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVDQREA PLNNFSVAQC QLMKTERPRP NTFIIRCLQW TTVIERTFHV ETPEEREEWT TAIQTVADGL KKQEEEEMDF RSGSPSDNSG AEEMEVSLAK PKHRVTMNEF EYLKLLGKGT FGKVILVKEK ATGRYYAMKI LKKEVIVAKD EVAHTLTENR VLQNSRHPFL TALKYSFQTH DRLCFVMEYA NGGELFFHLS RERVFSEDRA RFYGAEIVSA LDYLHSEKNV VYRDLKLENL MLDKDGHIKI TDFGLCKEGI KDGATMKTFC GTPEYLAPEV LEDNDYGRAV DWWGLGVVMY EMMCGRLPFY NQDHEKLFEL ILMEEIRFPR TLGPEAKSLL SGLLKKDPKQ RLGGGSEDAK EIMQHRFFAG IVWQHVYEKK LSPPFKPQVT SETDTRYFDE EFTAQMITIT PPDQDDSMEC VDSERRPHFP QFSYSASGTA
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