About Vasoactive intestinal polypeptide receptor 1
Vasoactive intestinal polypeptide receptor 1 (VIPR1) is a protein
from Homo sapiens identified by UniProt accession
P32241, 457 residues long.
MolForge cross-references it against 0 known binders and
247 disease associations.
Target properties
| Protein name | Vasoactive intestinal polypeptide receptor 1 |
|---|
| UniProt accession | P32241 |
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| Gene | VIPR1 |
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| Organism | Homo sapiens |
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| Length | 457 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (247)
Diseases linked to this target (Open Targets).
- hepatocellular carcinoma · score 0.11
- medulloblastoma · score 0.11
- neoplasm · score 0.09
- experimental autoimmune encephalomyelitis · score 0.08
- lean body mass · score 0.06
- Spinocerebellar ataxia type 40 · score 0.06
- lung adenocarcinoma · score 0.05
- spinocerebellar ataxia type 35 · score 0.05
- periodontitis · score 0.05
- spinocerebellar ataxia type 23 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P32241-F1 | alphafold | PREDICTED | 76.01 | — |
Amino-acid sequence (457 residues)
MRPPSPLPAR WLCVLAGALA WALGPAGGQA ARLQEECDYV QMIEVQHKQC LEEAQLENET IGCSKMWDNL TCWPATPRGQ VVVLACPLIF KLFSSIQGRN VSRSCTDEGW THLEPGPYPI ACGLDDKAAS LDEQQTMFYG SVKTGYTIGY GLSLATLLVA TAILSLFRKL HCTRNYIHMH LFISFILRAA AVFIKDLALF DSGESDQCSE GSVGCKAAMV FFQYCVMANF FWLLVEGLYL YTLLAVSFFS ERKYFWGYIL IGWGVPSTFT MVWTIARIHF EDYGCWDTIN SSLWWIIKGP ILTSILVNFI LFICIIRILL QKLRPPDIRK SDSSPYSRLA RSTLLLIPLF GVHYIMFAFF PDNFKPEVKM VFELVVGSFQ GFVVAILYCF LNGEVQAELR RKWRRWHLQG VLGWNPKYRH PSGGSNGATC STQVSMLTRV SPGARRSSSF QAEVSLV
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