Cefotiam

ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Cefotiam is an ofm drug catalogued in DrugCentral. DrugCentral lists 4 molecular targets, including VIPR1, MMP9 and pbpA.

• Approval status: ofm.
• Molecular targets: VIPR1, MMP9, pbpA and mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB (4 listed in DrugCentral).
• ATC code: J01DC07 (Second-generation cephalosporins).
• Molecular formula: C18H23N9O4S3; molecular weight 525.64 g/mol.

Mechanism & targets

Molecular targets (4)

Target	Gene	Action	Activity
Vasoactive intestinal polypeptide receptor 1	VIPR1	unknown	IC50 4.47
Matrix metalloproteinase-9	MMP9	unknown	IC50 4.46
Penicillin-binding protein 1A	pbpA	unknown	—
Bacterial penicillin-binding protein	mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
—	FDA	—	TAKEDA

ATC classification

ATC code	Therapeutic hierarchy
J01DC07	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER BETA-LACTAM ANTIBACTERIALS › Second-generation cephalosporins

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Toxic epidermal necrolysis	57.8

Chemical structure

• Molecular formula: C₁₈H₂₃N₉O₄S₃
• Molecular weight: 525.64 g/mol
• CAS number: —
• InChIKey: QYQDKDWGWDOFFU-IUODEOHRSA-N
• PubChem CID: 43708

CN(C)CCN1N=NN=C1SCC1=C(N2[C@H](SC1)[C@H](NC(=O)CC1=CSC(N)=N1)C2=O)C(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

How does Cefotiam work?

Its molecular targets in DrugCentral include VIPR1, MMP9, pbpA and mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB (inhibitor).

What is the chemical formula of Cefotiam?

Cefotiam has the molecular formula C18H23N9O4S3 and a molecular weight of 525.64 g/mol.

Sources

• DrugCentral drug card 548 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1296 — compound record and bioactivity
• PubChem CID 43708 — chemical identifiers
• DrugBank DB00229 — drug record
• FDA UNII 91W6Z2N718 — substance identity
• DailyMed: FDA labels for Cefotiam — current prescribing information (label search)
• UniProt P32241 (VIPR1) — target protein
• UniProt P14780 (MMP9) — target protein
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.