Cefprozil

Cephalosporin Antibacterial — ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Cefprozil is an ofp drug in the Cephalosporin Antibacterial class catalogued in DrugCentral. It was first approved by the FDA in 1991. DrugCentral lists 1 molecular target, including pbpA. Recorded indications include Acute bacterial bronchitis, Acute bacterial sinusitis, Acute exacerbation of chronic bronchitis and Acute Moraxella catarrhalis bronchitis.

• Approval status: ofp (first approved 1991 by the FDA).
• Drug class: Cephalosporin Antibacterial.
• Molecular targets: pbpA (1 listed in DrugCentral).
• Indications: Acute bacterial bronchitis, Acute bacterial sinusitis, Acute exacerbation of chronic bronchitis, Acute Moraxella catarrhalis bronchitis and Acute otitis media and others.
• ATC code: J01DC10 (Second-generation cephalosporins).
• Molecular formula: C18H19N3O5S; molecular weight 389.43 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (21)

• Acute bacterial bronchitis
• Acute bacterial sinusitis
• Acute exacerbation of chronic bronchitis
• Acute Moraxella catarrhalis bronchitis
• Acute otitis media
• Bronchitis
• Haemophilus Influenzae Acute Otitis Media
• Haemophilus Influenzae Bronchitis
• Haemophilus Influenzae Chronic Bronchitis
• Infection due to Staphylococcus aureus
• Infection of skin AND/OR subcutaneous tissue
• Infective otitis media
• Moraxella Catarrhalis Acute Otitis Media
• Moraxella Catarrhalis Chronic Bronchitis
• Pneumococcal Acute Otitis Media
• Streptococcal tonsillitis
• Streptococcus Pneumoniae Bronchitis
• Streptococcus Pneumoniae Chronic Bronchitis
• Streptococcus pyogenes infection
• Tonsillitis
• Upper respiratory infection

Off-label uses (1)

• Pyrexia of unknown origin

Contraindications (3)

• Acute nephropathy
• Factor II deficiency
• Pseudomembranous enterocolitis

Mechanism & targets

• Established pharmacologic class: Cephalosporin Antibacterial

Molecular targets (1)

Target	Gene	Action	Activity
Penicillin-binding protein 1A	pbpA	unknown	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1991-12-23	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
J01DC10	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER BETA-LACTAM ANTIBACTERIALS › Second-generation cephalosporins

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Drug hypersensitivity	90.0
Mouth breathing	82.7
Urticaria	53.4
Sputum discoloured	47.5
Heat exhaustion	43.7
Clostridium difficile colitis	39.6
Snoring	39.5
Choking	38.2
Oropharyngeal pain	37.7
Pneumonia mycoplasmal	34.9
Cough	34.4
Product storage error	34.0

Chemical structure

• Molecular formula: C₁₈H₁₉N₃O₅S
• Molecular weight: 389.43 g/mol
• CAS number: 92665-29-7
• InChIKey: WDLWHQDACQUCJR-ZAMMOSSLSA-N
• PubChem CID: 62977

C\C=C\C1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](N)C1=CC=C(O)C=C1)C2=O)C(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Cefprozil used for?

DrugCentral lists the following indications for Cefprozil: Acute bacterial bronchitis, Acute bacterial sinusitis, Acute exacerbation of chronic bronchitis, Acute Moraxella catarrhalis bronchitis, Acute otitis media, Bronchitis, Haemophilus Influenzae Acute Otitis Media and Haemophilus Influenzae Bronchitis and others.

How does Cefprozil work?

Its molecular targets in DrugCentral include pbpA.

When was Cefprozil first approved?

Cefprozil was first approved by the FDA in 1991.

What drug class does Cefprozil belong to?

Cefprozil is in the Cephalosporin Antibacterial class.

What is the chemical formula of Cefprozil?

Cefprozil has the molecular formula C18H19N3O5S and a molecular weight of 389.43 g/mol.

Sources

• DrugCentral drug card 556 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL3301800 — compound record and bioactivity
• PubChem CID 62977 — chemical identifiers
• DrugBank DB01150 — drug record
• FDA UNII 4W0459ZA4V — substance identity
• DailyMed: FDA labels for Cefprozil — current prescribing information (label search)
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.