Cefoxitin

Cephalosporin Antibacterial — ANTIINFECTIVES FOR SYSTEMIC USE

Key facts

Cefoxitin is an ofp drug in the Cephalosporin Antibacterial class catalogued in DrugCentral. It was first approved by the FDA in 1978. DrugCentral lists 7 molecular targets, including Beta-lactamase, blaPER-2 and ampC. Recorded indications include Abdominal abscess, Abscess of lung, Acute gonococcal cervicitis and Acute gonococcal endometritis.

• Approval status: ofp (first approved 1978 by the FDA).
• Drug class: Cephalosporin Antibacterial.
• Molecular targets: Beta-lactamase, blaPER-2, ampC and ska (7 listed in DrugCentral).
• Indications: Abdominal abscess, Abscess of lung, Acute gonococcal cervicitis, Acute gonococcal endometritis and Bacterial infection due to Klebsiella pneumoniae and others.
• ATC code: J01DC01 (Second-generation cephalosporins).
• Molecular formula: C16H17N3O7S2; molecular weight 427.45 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (82)

• Abdominal abscess
• Abscess of lung
• Acute gonococcal cervicitis
• Acute gonococcal endometritis
• Bacterial infection due to Klebsiella pneumoniae
• Bacterial pneumonia
• Bacterial septicemia
• Bacterial urinary infection
• Bacteroides Endometritis
• Bacteroides Lung Abscess
• Bacteroides Pelvic Cellulitis
• Bacteroides Pelvic Inflammatory Disease
• Bacteroides Peritonitis
• Bacteroides Pneumonia
• Cesarean Section Infection Prevention
• Clostridium Endometritis
• Clostridium Pelvic Cellulitis
• Clostridium Pelvic Inflammatory Disease
• Clostridium Peritonitis
• E. Coli Endometritis
• E. Coli Lung Abscess
• E. Coli Pelvic Cellulitis
• E. Coli Pelvic Inflammatory Disease
• E. Coli Peritonitis
• Endometritis
• Escherichia coli urinary tract infection
• Female genital tract infection
• Female pelvic cellulitis
• Gonorrhea
• Group B Streptococcus Pelvic Inflammatory Disease
• + 52 more

Off-label uses (2)

• Acute gonococcal urethritis
• Gonorrhea of rectum

Contraindications (3)

• Colitis
• Kidney disease
• Pseudomembranous enterocolitis

Mechanism & targets

• Established pharmacologic class: Cephalosporin Antibacterial

Molecular targets (7)

Target	Gene	Action	Activity
Beta-lactamase	—	unknown	Ki 7.00
Beta-lactamase	blaPER-2	unknown	Ki 6.85
Beta-lactamase	ampC	unknown	Ki 6.30
Streptokinase A	ska	unknown	EC50 5.48
Penicillin-binding protein 1A	pbpA	unknown	—
Beta-lactamase	penP	unknown	—
Bacterial penicillin-binding protein	mrcA|mrcB|dacC|mrdA|ftsI|dacA|dacB	inhibitor	—

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
1978-10-18	FDA	—	—

ATC classification

ATC code	Therapeutic hierarchy
J01DC01	ANTIINFECTIVES FOR SYSTEMIC USE › ANTIBACTERIALS FOR SYSTEMIC USE › OTHER BETA-LACTAM ANTIBACTERIALS › Second-generation cephalosporins

Reported adverse-event signals

Strongest FDA FAERS disproportionality signals (log-likelihood ratio). A signal is a statistical association in spontaneous reports, not proof that the drug causes the event.

MedDRA term	LLR
Drug resistance	258.1
Drug reaction with eosinophilia and systemic symptoms	202.5
Ototoxicity	151.6
Systemic mastocytosis	94.4
Pathogen resistance	92.6
Rash maculo-papular	79.2
Anaphylactic shock	78.7
Mycobacterium abscessus infection	60.4
Thrombocytopenia	58.4
Anaphylactic reaction	52.4
Mycobacterium chelonae infection	46.1
Product use in unapproved indication	44.8

Chemical structure

• Molecular formula: C₁₆H₁₇N₃O₇S₂
• Molecular weight: 427.45 g/mol
• CAS number: 35607-66-0
• InChIKey: WZOZEZRFJCJXNZ-ZBFHGGJFSA-N
• PubChem CID: 441199

CO[C@]1(NC(=O)CC2=CC=CS2)[C@H]2SCC(COC(N)=O)=C(N2C1=O)C(O)=O

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Cefoxitin used for?

DrugCentral lists the following indications for Cefoxitin: Abdominal abscess, Abscess of lung, Acute gonococcal cervicitis, Acute gonococcal endometritis, Bacterial infection due to Klebsiella pneumoniae, Bacterial pneumonia, Bacterial septicemia and Bacterial urinary infection and others.

How does Cefoxitin work?

Its molecular targets in DrugCentral include Beta-lactamase, blaPER-2, ampC and ska.

When was Cefoxitin first approved?

Cefoxitin was first approved by the FDA in 1978.

What drug class does Cefoxitin belong to?

Cefoxitin is in the Cephalosporin Antibacterial class.

What is the chemical formula of Cefoxitin?

Cefoxitin has the molecular formula C16H17N3O7S2 and a molecular weight of 427.45 g/mol.

Sources

• DrugCentral drug card 550 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL1200530 — compound record and bioactivity
• PubChem CID 441199 — chemical identifiers
• DrugBank DB01331 — drug record
• FDA UNII 6OEV9DX57Y — substance identity
• DailyMed: FDA labels for Cefoxitin — current prescribing information (label search)
• FDA Adverse Event Reporting System (openFDA FAERS) — adverse-event signals, as aggregated by DrugCentral

How this page is built: methodology · editorial policy & corrections.