C-C chemokine receptor type 1 (CCR1)

About C-C chemokine receptor type 1

C-C chemokine receptor type 1 (CCR1) is a protein from Homo sapiens identified by UniProt accession P32246, 355 residues long. MolForge cross-references it against 0 known binders and 522 disease associations.

Target properties

Protein name	C-C chemokine receptor type 1
UniProt accession	P32246
Gene	CCR1
Organism	Homo sapiens
Length	355 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (522)

Diseases linked to this target (Open Targets).

basophil count · score 0.27
glioblastoma multiforme · score 0.26
celiac disease · score 0.23
mean corpuscular hemoglobin · score 0.22
basophil percentage of leukocytes · score 0.18
mean corpuscular volume · score 0.18
breast adenocarcinoma · score 0.17
head and neck squamous cell carcinoma · score 0.17
CCL4 measurement · score 0.16
Behcet's syndrome · score 0.15

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P32246-F1	alphafold	PREDICTED	83.18	—

Amino-acid sequence (355 residues)

METPNTTEDY DTTTEFDYGD ATPCQKVNER AFGAQLLPPL YSLVFVIGLV GNILVVLVLV QYKRLKNMTS IYLLNLAISD LLFLFTLPFW IDYKLKDDWV FGDAMCKILS GFYYTGLYSE IFFIILLTID RYLAIVHAVF ALRARTVTFG VITSIIIWAL AILASMPGLY FSKTQWEFTH HTCSLHFPHE SLREWKLFQA LKLNLFGLVL PLLVMIICYT GIIKILLRRP NEKKSKAVRL IFVIMIIFFL FWTPYNLTIL ISVFQDFLFT HECEQSRHLD LAVQVTEVIA YTHCCVNPVI YAFVGERFRK YLRQLFHRRV AVHLVKWLPF LSVDRLERVS STSPSTGEHE LSAGF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards