Abametapir

ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS

Key facts

Abametapir is an ofm drug catalogued in DrugCentral. It was first approved by the FDA in 2020. DrugCentral lists 4 molecular targets, including HDAC6, CCR5 and CCR8. Recorded indications include Pediculosis capitis.

• Approval status: ofm (first approved 2020 by the FDA).
• Molecular targets: HDAC6, CCR5, CCR8 and CCR1 (4 listed in DrugCentral).
• Indications: Pediculosis capitis.
• ATC code: P03AX07 (Other ectoparasiticides, incl. scabicides).
• Molecular formula: C12H12N2; molecular weight 184.24 g/mol.

Indications & contraindications

Drug–disease relationships curated by DrugCentral (OMOP / SNOMED concepts).

Indications (1)

• Pediculosis capitis

Mechanism & targets

Molecular targets (4)

Target	Gene	Action	Activity
Histone deacetylase 6	HDAC6	unknown	IC50 5.99
C-C chemokine receptor type 5	CCR5	unknown	EC50 5.64
C-C chemokine receptor type 8	CCR8	unknown	EC50 5.12
C-C chemokine receptor type 1	CCR1	unknown	EC50 4.80

Regulatory approvals (1)

Date	Agency	Marketed as	Applicant	Orphan
2020-07-24	FDA	—	DR REDDYS LABS SA

ATC classification

ATC code	Therapeutic hierarchy
P03AX07	ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS › ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS › ECTOPARASITICIDES, INCL. SCABICIDES › Other ectoparasiticides, incl. scabicides

Chemical structure

Full physicochemical, ADMET and 3D-structure analysis of Abametapir is on its molecule page.

• Molecular formula: C₁₂H₁₂N₂
• Molecular weight: 184.24 g/mol
• CAS number: 1762-34-1
• InChIKey: PTRATZCAGVBFIQ-UHFFFAOYSA-N
• PubChem CID: 15664

CC1=CN=C(C=C1)C2=NC=C(C=C2)C

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

What is Abametapir used for?

DrugCentral lists the following indications for Abametapir: Pediculosis capitis.

How does Abametapir work?

Its molecular targets in DrugCentral include HDAC6, CCR5, CCR8 and CCR1.

When was Abametapir first approved?

Abametapir was first approved by the FDA in 2020.

What is the chemical formula of Abametapir?

Abametapir has the molecular formula C12H12N2 and a molecular weight of 184.24 g/mol.

Sources

• DrugCentral drug card 5403 — structure, indications, targets, approvals, pharmacologic classes (CC BY-SA 4.0)
• ChEMBL CHEMBL2205807 — compound record and bioactivity
• PubChem CID 15664 — chemical identifiers
• DrugBank DB11932 — drug record
• FDA UNII 6UO390AMFB — substance identity
• DailyMed: FDA labels for Abametapir — current prescribing information (label search)
• UniProt Q9UBN7 (HDAC6) — target protein
• UniProt P51681 (CCR5) — target protein
• UniProt P51685 (CCR8) — target protein
• UniProt P32246 (CCR1) — target protein

How this page is built: methodology · editorial policy & corrections.