C-C chemokine receptor type 5 (CCR5)

About C-C chemokine receptor type 5

C-C chemokine receptor type 5 (CCR5) is a protein from Homo sapiens identified by UniProt accession P51681, 352 residues long. MolForge cross-references it against 0 known binders and 840 disease associations.

Target properties

Protein name	C-C chemokine receptor type 5
UniProt accession	P51681
Gene	CCR5
Organism	Homo sapiens
Length	352 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (4)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (840)

Diseases linked to this target (Open Targets).

HIV infection · score 0.74
HIV-1 infection · score 0.66
AIDS · score 0.58
infection · score 0.47
viral disease · score 0.40
endothelial dysfunction · score 0.37
immunodeficiency disease · score 0.37
COVID-19 · score 0.34
monocyte percentage of leukocytes · score 0.31
blood protein measurement · score 0.30

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-P51681-F1	alphafold	PREDICTED	85.36	—

Amino-acid sequence (352 residues)

MDYQVSSPIY DINYYTSEPC QKINVKQIAA RLLPPLYSLV FIFGFVGNML VILILINCKR LKSMTDIYLL NLAISDLFFL LTVPFWAHYA AAQWDFGNTM CQLLTGLYFI GFFSGIFFII LLTIDRYLAV VHAVFALKAR TVTFGVVTSV ITWVVAVFAS LPGIIFTRSQ KEGLHYTCSS HFPYSQYQFW KNFQTLKIVI LGLVLPLLVM VICYSGILKT LLRCRNEKKR HRAVRLIFTI MIVYFLFWAP YNIVLLLNTF QEFFGLNNCS SSNRLDQAMQ VTETLGMTHC CINPIIYAFV GEKFRNYLLV FFQKHIAKRF CKCCSIFQQE APERASSVYT RSTGEQEISV GL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards