About Neuronal acetylcholine receptor subunit alpha-3
Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3) is a protein
from Homo sapiens identified by UniProt accession
P32297, 505 residues long.
MolForge cross-references it against 0 known binders and
175 disease associations.
Target properties
| Protein name | Neuronal acetylcholine receptor subunit alpha-3 |
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| UniProt accession | P32297 |
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| Gene | CHRNA3 |
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| Organism | Homo sapiens |
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| Length | 505 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (6)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (175)
Diseases linked to this target (Open Targets).
- urinary bladder, atony of · score 0.65
- congenital anomaly of kidney and urinary tract · score 0.55
- chronic obstructive pulmonary disease · score 0.47
- hypertension · score 0.47
- Abnormal autonomic nervous system physiology · score 0.46
- autonomic nervous system disease · score 0.46
- cigarettes per day measurement · score 0.42
- schizophrenia · score 0.41
- emphysema pattern measurement · score 0.41
- smoking behavior · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-P32297-F1 | alphafold | PREDICTED | 81.12 | — |
Amino-acid sequence (505 residues)
MGSGPLSLPL ALSPPRLLLL LLLSLLPVAR ASEAEHRLFE RLFEDYNEII RPVANVSDPV IIHFEVSMSQ LVKVDEVNQI METNLWLKQI WNDYKLKWNP SDYGGAEFMR VPAQKIWKPD IVLYNNAVGD FQVDDKTKAL LKYTGEVTWI PPAIFKSSCK IDVTYFPFDY QNCTMKFGSW SYDKAKIDLV LIGSSMNLKD YWESGEWAII KAPGYKHDIK YNCCEEIYPD ITYSLYIRRL PLFYTINLII PCLLISFLTV LVFYLPSDCG EKVTLCISVL LSLTVFLLVI TETIPSTSLV IPLIGEYLLF TMIFVTLSIV ITVFVLNVHY RTPTTHTMPS WVKTVFLNLL PRVMFMTRPT SNEGNAQKPR PLYGAELSNL NCFSRAESKG CKEGYPCQDG MCGYCHHRRI KISNFSANLT RSSSSESVDA VLSLSALSPE IKEAIQSVKY IAENMKAQNE AKEIQDDWKY VAMVIDRIFL WVFTLVCILG TAGLFLQPLM AREDA
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